% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Peterziel:186513,
      author       = {H. Peterziel$^*$ and N. Jamaladdin$^*$ and D. ElHarouni$^*$
                      and X. Gerloff$^*$ and S. Herter$^*$ and P. Fiesel$^*$ and
                      Y. Berker$^*$ and M. Blattner-Johnson$^*$ and K. Schramm$^*$
                      and B. Jones$^*$ and D. Reuss and L. Turunen and A.
                      Friedenauer$^*$ and T. Holland-Letz$^*$ and M. Sill$^*$ and
                      L. Weiser$^*$ and C. Previti$^*$ and G. Balasubramanian$^*$
                      and N. U. Gerber and J. Gojo and C. Hutter and I. Øra and
                      O. Lohi and A. Kattamis and B. de Wilde and F.
                      Westermann$^*$ and S. Tippelt and N. Graf and M. Nathrath
                      and M. Sparber-Sauer and A. Sehested and C. M. Kramm and U.
                      Dirksen and O. Kallioniemi and S. Pfister$^*$ and C. M. van
                      Tilburg$^*$ and D. Jones$^*$ and J. Saarela and V.
                      Pietiäinen and N. Jäger$^*$ and M. Schlesner$^*$ and A.
                      Kopp-Schneider$^*$ and S. Oppermann$^*$ and T. Milde$^*$ and
                      O. Witt$^*$ and I. Oehme$^*$},
      title        = {{D}rug sensitivity profiling of 3{D} tumor tissue cultures
                      in the pediatric precision oncology program {INFORM}.},
      journal      = {npj precision oncology},
      volume       = {6},
      number       = {1},
      issn         = {2397-768X},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2022-03215},
      pages        = {94},
      year         = {2022},
      note         = {#EA:B310#LA:B310#},
      abstract     = {The international precision oncology program INFORM enrolls
                      relapsed/refractory pediatric cancer patients for
                      comprehensive molecular analysis. We report a two-year pilot
                      study implementing ex vivo drug sensitivity profiling (DSP)
                      using a library of 75-78 clinically relevant drugs. We
                      included 132 viable tumor samples from 35 pediatric oncology
                      centers in seven countries. DSP was conducted on
                      multicellular fresh tumor tissue spheroid cultures in
                      384-well plates with an overall mean processing time of
                      three weeks. In 89 cases $(67\%),$ sufficient viable tissue
                      was received; 69 $(78\%)$ passed internal quality controls.
                      The DSP results matched the identified molecular targets,
                      including BRAF, ALK, MET, and TP53 status. Drug
                      vulnerabilities were identified in $80\%$ of cases lacking
                      actionable (very) high-evidence molecular events, adding
                      value to the molecular data. Striking parallels between
                      clinical courses and the DSP results were observed in
                      selected patients. Overall, DSP in clinical real-time is
                      feasible in international multicenter precision oncology
                      programs.},
      cin          = {B310 / HD01 / B240 / B062 / B300 / B360 / C060 / W610 /
                      B087},
      ddc          = {610},
      cid          = {I:(DE-He78)B310-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)B240-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)B300-20160331 / I:(DE-He78)B360-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)W610-20160331 /
                      I:(DE-He78)B087-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36575299},
      doi          = {10.1038/s41698-022-00335-y},
      url          = {https://inrepo02.dkfz.de/record/186513},
}