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| 001 | 186513 | ||
| 005 | 20240229145749.0 | ||
| 024 | 7 | _ | |a 10.1038/s41698-022-00335-y |2 doi |
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| 100 | 1 | _ | |a Peterziel, Heike |0 P:(DE-He78)2727b5cb63b52d0137d4f4e8f110ee7e |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM. |
| 260 | _ | _ | |a [London] |c 2022 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a library of 75-78 clinically relevant drugs. We included 132 viable tumor samples from 35 pediatric oncology centers in seven countries. DSP was conducted on multicellular fresh tumor tissue spheroid cultures in 384-well plates with an overall mean processing time of three weeks. In 89 cases (67%), sufficient viable tissue was received; 69 (78%) passed internal quality controls. The DSP results matched the identified molecular targets, including BRAF, ALK, MET, and TP53 status. Drug vulnerabilities were identified in 80% of cases lacking actionable (very) high-evidence molecular events, adding value to the molecular data. Striking parallels between clinical courses and the DSP results were observed in selected patients. Overall, DSP in clinical real-time is feasible in international multicenter precision oncology programs. |
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| 773 | _ | _ | |a 10.1038/s41698-022-00335-y |g Vol. 6, no. 1, p. 94 |0 PERI:(DE-600)2891458-2 |n 1 |p 94 |t npj precision oncology |v 6 |y 2022 |x 2397-768X |
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