%0 Journal Article
%A Visvanathan, Kala
%A Mondul, Alison M
%A Zeleniuch-Jacquotte, Anne
%A Wang, Molin
%A Gail, Mitchell H
%A Yaun, Shiaw-Shyuan
%A Weinstein, Stephanie J
%A McCullough, Marjorie L
%A Eliassen, A Heather
%A Cook, Nancy R
%A Agnoli, Claudia
%A Almquist, Martin
%A Black, Amanda
%A Buring, Julie E
%A Chen, Chu
%A Chen, Yu
%A Clendenen, Tess
%A Dossus, Laure
%A Fedirko, Veronika
%A Gierach, Gretchen L
%A Giovannucci, Edward L
%A Goodman, Gary E
%A Goodman, Marc T
%A Guénel, Pascal
%A Hallmans, Göran
%A Hankinson, Susan E
%A Horst, Ronald L
%A Hou, Tao
%A Huang, Wen-Yi
%A Jones, Michael E
%A Joshu, Corrine E
%A Kaaks, Rudolf
%A Krogh, Vittorio
%A Kühn, Tilman
%A Kvaskoff, Marina
%A Lee, I-Min
%A Mahamat-Saleh, Yahya
%A Malm, Johan
%A Manjer, Jonas
%A Maskarinec, Gertraud
%A Millen, Amy E
%A Mukhtar, Toqir K
%A Neuhouser, Marian L
%A Robsahm, Trude E
%A Schoemaker, Minouk J
%A Sieri, Sabina
%A Sund, Malin
%A Swerdlow, Anthony J
%A Thomson, Cynthia A
%A Ursin, Giske
%A Wactawski-Wende, Jean
%A Wang, Ying
%A Wilkens, Lynne R
%A Wu, Yujie
%A Zoltick, Emilie
%A Willett, Walter C
%A Smith-Warner, Stephanie A
%A Ziegler, Regina G
%T Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts.
%J European journal of epidemiology
%V 38
%N 1
%@ 0393-2990
%C Dordrecht [u.a.]
%I Springer Science + Business Media B.V.
%M DKFZ-2023-00013
%P 11-29
%D 2023
%Z 2023 Jan;38(1):11-29
%X Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S. and 7 European prospective cohorts. Included were 10,484 invasive breast cancer cases and 12,953 matched controls. Median age (interdecile range) was 57 (42-68) years at blood collection and 63 (49-75) years at breast cancer diagnosis. Prediagnostic circulating 25(OH)D was either newly measured using a widely accepted immunoassay and laboratory or, if previously measured by the cohort, calibrated to this assay to permit using a common metric. Study-specific relative risks (RRs) for season-standardized 25(OH)D concentrations were estimated by conditional logistic regression and combined by random-effects models. Circulating 25(OH)D increased from a median of 22.6 nmol/L in consortium-wide decile 1 to 93.2 nmol/L in decile 10. Breast cancer risk in each decile was not statistically significantly different from risk in decile 5 in models adjusted for breast cancer risk factors, and no trend was apparent (P-trend = 0.64). Compared to women with sufficient 25(OH)D based on Institute of Medicine guidelines (50- < 62.5 nmol/L), RRs were not statistically significantly different at either low concentrations (< 20 nmol/L, 3
%K 25-Hydroxyvitamin D (Other)
%K Biomarker (Other)
%K Breast cancer (Other)
%K Calibration (Other)
%K Pooled analysis (Other)
%K Prospective cohort study (Other)
%K Vitamin D (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36593337
%R 10.1007/s10654-022-00921-1
%U https://inrepo02.dkfz.de/record/186561