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000186561 0247_ $$2doi$$a10.1007/s10654-022-00921-1
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000186561 0247_ $$2ISSN$$a1573-7284
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000186561 037__ $$aDKFZ-2023-00013
000186561 041__ $$aEnglish
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000186561 1001_ $$aVisvanathan, Kala$$b0
000186561 245__ $$aCirculating vitamin D and breast cancer risk: an international pooling project of 17 cohorts.
000186561 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2023
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000186561 500__ $$a2023 Jan;38(1):11-29
000186561 520__ $$aLaboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S. and 7 European prospective cohorts. Included were 10,484 invasive breast cancer cases and 12,953 matched controls. Median age (interdecile range) was 57 (42-68) years at blood collection and 63 (49-75) years at breast cancer diagnosis. Prediagnostic circulating 25(OH)D was either newly measured using a widely accepted immunoassay and laboratory or, if previously measured by the cohort, calibrated to this assay to permit using a common metric. Study-specific relative risks (RRs) for season-standardized 25(OH)D concentrations were estimated by conditional logistic regression and combined by random-effects models. Circulating 25(OH)D increased from a median of 22.6 nmol/L in consortium-wide decile 1 to 93.2 nmol/L in decile 10. Breast cancer risk in each decile was not statistically significantly different from risk in decile 5 in models adjusted for breast cancer risk factors, and no trend was apparent (P-trend = 0.64). Compared to women with sufficient 25(OH)D based on Institute of Medicine guidelines (50- < 62.5 nmol/L), RRs were not statistically significantly different at either low concentrations (< 20 nmol/L, 3% of controls) or high concentrations (100- < 125 nmol/L, 3% of controls; ≥ 125 nmol/L, 0.7% of controls). RR per 25 nmol/L increase in 25(OH)D was 0.99 [95% confidence intervaI (CI) 0.95-1.03]. Associations remained null across subgroups, including those defined by body mass index, physical activity, latitude, and season of blood collection. Although none of the associations by tumor characteristics reached statistical significance, suggestive inverse associations were seen for distant and triple negative tumors. Circulating 25(OH)D, comparably measured in 17 international cohorts and season-standardized, was not related to subsequent incidence of invasive breast cancer over a broad range in vitamin D status.
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000186561 650_7 $$2Other$$a25-Hydroxyvitamin D
000186561 650_7 $$2Other$$aBiomarker
000186561 650_7 $$2Other$$aBreast cancer
000186561 650_7 $$2Other$$aCalibration
000186561 650_7 $$2Other$$aPooled analysis
000186561 650_7 $$2Other$$aProspective cohort study
000186561 650_7 $$2Other$$aVitamin D
000186561 7001_ $$aMondul, Alison M$$b1
000186561 7001_ $$aZeleniuch-Jacquotte, Anne$$b2
000186561 7001_ $$aWang, Molin$$b3
000186561 7001_ $$aGail, Mitchell H$$b4
000186561 7001_ $$aYaun, Shiaw-Shyuan$$b5
000186561 7001_ $$aWeinstein, Stephanie J$$b6
000186561 7001_ $$aMcCullough, Marjorie L$$b7
000186561 7001_ $$aEliassen, A Heather$$b8
000186561 7001_ $$aCook, Nancy R$$b9
000186561 7001_ $$aAgnoli, Claudia$$b10
000186561 7001_ $$aAlmquist, Martin$$b11
000186561 7001_ $$aBlack, Amanda$$b12
000186561 7001_ $$aBuring, Julie E$$b13
000186561 7001_ $$aChen, Chu$$b14
000186561 7001_ $$aChen, Yu$$b15
000186561 7001_ $$aClendenen, Tess$$b16
000186561 7001_ $$aDossus, Laure$$b17
000186561 7001_ $$aFedirko, Veronika$$b18
000186561 7001_ $$aGierach, Gretchen L$$b19
000186561 7001_ $$aGiovannucci, Edward L$$b20
000186561 7001_ $$aGoodman, Gary E$$b21
000186561 7001_ $$aGoodman, Marc T$$b22
000186561 7001_ $$aGuénel, Pascal$$b23
000186561 7001_ $$aHallmans, Göran$$b24
000186561 7001_ $$aHankinson, Susan E$$b25
000186561 7001_ $$aHorst, Ronald L$$b26
000186561 7001_ $$aHou, Tao$$b27
000186561 7001_ $$aHuang, Wen-Yi$$b28
000186561 7001_ $$aJones, Michael E$$b29
000186561 7001_ $$aJoshu, Corrine E$$b30
000186561 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b31$$udkfz
000186561 7001_ $$aKrogh, Vittorio$$b32
000186561 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b33
000186561 7001_ $$aKvaskoff, Marina$$b34
000186561 7001_ $$aLee, I-Min$$b35
000186561 7001_ $$aMahamat-Saleh, Yahya$$b36
000186561 7001_ $$aMalm, Johan$$b37
000186561 7001_ $$aManjer, Jonas$$b38
000186561 7001_ $$aMaskarinec, Gertraud$$b39
000186561 7001_ $$aMillen, Amy E$$b40
000186561 7001_ $$aMukhtar, Toqir K$$b41
000186561 7001_ $$aNeuhouser, Marian L$$b42
000186561 7001_ $$aRobsahm, Trude E$$b43
000186561 7001_ $$aSchoemaker, Minouk J$$b44
000186561 7001_ $$aSieri, Sabina$$b45
000186561 7001_ $$aSund, Malin$$b46
000186561 7001_ $$aSwerdlow, Anthony J$$b47
000186561 7001_ $$aThomson, Cynthia A$$b48
000186561 7001_ $$aUrsin, Giske$$b49
000186561 7001_ $$aWactawski-Wende, Jean$$b50
000186561 7001_ $$aWang, Ying$$b51
000186561 7001_ $$aWilkens, Lynne R$$b52
000186561 7001_ $$aWu, Yujie$$b53
000186561 7001_ $$aZoltick, Emilie$$b54
000186561 7001_ $$aWillett, Walter C$$b55
000186561 7001_ $$aSmith-Warner, Stephanie A$$b56
000186561 7001_ $$00000-0002-5100-9852$$aZiegler, Regina G$$b57
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