TY  - JOUR
AU  - Visvanathan, Kala
AU  - Mondul, Alison M
AU  - Zeleniuch-Jacquotte, Anne
AU  - Wang, Molin
AU  - Gail, Mitchell H
AU  - Yaun, Shiaw-Shyuan
AU  - Weinstein, Stephanie J
AU  - McCullough, Marjorie L
AU  - Eliassen, A Heather
AU  - Cook, Nancy R
AU  - Agnoli, Claudia
AU  - Almquist, Martin
AU  - Black, Amanda
AU  - Buring, Julie E
AU  - Chen, Chu
AU  - Chen, Yu
AU  - Clendenen, Tess
AU  - Dossus, Laure
AU  - Fedirko, Veronika
AU  - Gierach, Gretchen L
AU  - Giovannucci, Edward L
AU  - Goodman, Gary E
AU  - Goodman, Marc T
AU  - Guénel, Pascal
AU  - Hallmans, Göran
AU  - Hankinson, Susan E
AU  - Horst, Ronald L
AU  - Hou, Tao
AU  - Huang, Wen-Yi
AU  - Jones, Michael E
AU  - Joshu, Corrine E
AU  - Kaaks, Rudolf
AU  - Krogh, Vittorio
AU  - Kühn, Tilman
AU  - Kvaskoff, Marina
AU  - Lee, I-Min
AU  - Mahamat-Saleh, Yahya
AU  - Malm, Johan
AU  - Manjer, Jonas
AU  - Maskarinec, Gertraud
AU  - Millen, Amy E
AU  - Mukhtar, Toqir K
AU  - Neuhouser, Marian L
AU  - Robsahm, Trude E
AU  - Schoemaker, Minouk J
AU  - Sieri, Sabina
AU  - Sund, Malin
AU  - Swerdlow, Anthony J
AU  - Thomson, Cynthia A
AU  - Ursin, Giske
AU  - Wactawski-Wende, Jean
AU  - Wang, Ying
AU  - Wilkens, Lynne R
AU  - Wu, Yujie
AU  - Zoltick, Emilie
AU  - Willett, Walter C
AU  - Smith-Warner, Stephanie A
AU  - Ziegler, Regina G
TI  - Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts.
JO  - European journal of epidemiology
VL  - 38
IS  - 1
SN  - 0393-2990
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2023-00013
SP  - 11-29
PY  - 2023
N1  - 2023 Jan;38(1):11-29
AB  - Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-hydroxyvitamin D [25(OH)D] to subsequent breast cancer incidence, we harmonized and pooled participant-level data from 10 U.S. and 7 European prospective cohorts. Included were 10,484 invasive breast cancer cases and 12,953 matched controls. Median age (interdecile range) was 57 (42-68) years at blood collection and 63 (49-75) years at breast cancer diagnosis. Prediagnostic circulating 25(OH)D was either newly measured using a widely accepted immunoassay and laboratory or, if previously measured by the cohort, calibrated to this assay to permit using a common metric. Study-specific relative risks (RRs) for season-standardized 25(OH)D concentrations were estimated by conditional logistic regression and combined by random-effects models. Circulating 25(OH)D increased from a median of 22.6 nmol/L in consortium-wide decile 1 to 93.2 nmol/L in decile 10. Breast cancer risk in each decile was not statistically significantly different from risk in decile 5 in models adjusted for breast cancer risk factors, and no trend was apparent (P-trend = 0.64). Compared to women with sufficient 25(OH)D based on Institute of Medicine guidelines (50- < 62.5 nmol/L), RRs were not statistically significantly different at either low concentrations (< 20 nmol/L, 3
KW  - 25-Hydroxyvitamin D (Other)
KW  - Biomarker (Other)
KW  - Breast cancer (Other)
KW  - Calibration (Other)
KW  - Pooled analysis (Other)
KW  - Prospective cohort study (Other)
KW  - Vitamin D (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36593337
DO  - DOI:10.1007/s10654-022-00921-1
UR  - https://inrepo02.dkfz.de/record/186561
ER  -