TY  - JOUR
AU  - Okumus, Özlem
AU  - Mardanzai, Khaled
AU  - Plönes, Till
AU  - Theegarten, Dirk
AU  - Darwiche, Kaid
AU  - Schuler, Martin
AU  - Nensa, Felix
AU  - Hautzel, Hubertus
AU  - Hermann, Ken
AU  - Stuschke, Martin
AU  - Hegedus, Balazs
AU  - Aigner, Clemens
TI  - Preoperative PET-SUVmax and volume based PET parameters of the primary tumor fail to predict nodal upstaging in early-stage lung cancer.
JO  - Lung cancer
VL  - 176
SN  - 0169-5002
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-00060
SP  - 82 - 88
PY  - 2023
AB  - Accurate nodal staging is of utmost importance in patients with lung cancer. FDG-PET/CT imaging is now part of the routine staging. Despite thorough preoperative staging nodal upstaging still occurs in early-stage lung cancer. However, the predictive value of preoperative PET metrics of the primary tumor on nodal upstaging remains to be unexplored. Our aim was to assess the association of these preoperative PET-parameters with nodal upstaging in histologically confirmed lung adenocarcinoma and squamous cell carcinoma.From January 2016 to November 2018, 500 patients with pT1-T2/cN0 lung cancer received an anatomical resection with curative intent. 171 patients with adenocarcinoma and squamous cell carcinoma and available PET-CTs were retrospectively included. We analyzed the the association of nodal upstaging with preoperative PET-SUVmax and metabolic PET metrics including total lesion glycolysis (TLG) and metabolic tumor volume (MTV) with different defined thresholds.High values of preoperative PET-SUVmax of the primary tumor were associated with squamous cell carcinoma (p < 0.0001) and with larger tumors (p < 0.0001). Increased preoperative C-reactive protein levels (<1mg/dL) correlated significantly with high preoperative PET-SUVmax values (p < 0.0001). No significant relationship between PET-SUVmax and lactate dehydrogenase activity (p = 0.6818), white blood cell count (p = 0.7681), gender (p = 0.1115) or age (p = 0.9284) was observed. Nodal upstaging rate was 14.0 
KW  - CRP (Other)
KW  - Lung cancer (Other)
KW  - MTV (Other)
KW  - Nodal upstaging (Other)
KW  - PET-SUVmax (Other)
KW  - TLG (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36623341
DO  - DOI:10.1016/j.lungcan.2022.12.013
UR  - https://inrepo02.dkfz.de/record/186691
ER  -