%0 Journal Article
%A Su, Yu-Ru
%A Sakoda, Lori C
%A Jeon, Jihyoun
%A Thomas, Minta
%A Lin, Yi
%A Schneider, Jennifer L
%A Udaltsova, Natalia
%A Lee, Jeffrey K
%A Lansdorp-Vogelaar, Iris
%A Peterse, Elisabeth F P
%A Zauber, Ann G
%A Zheng, Jiayin
%A Zheng, Yingye
%A Hauser, Elizabeth
%A Baron, John A
%A Barry, Elizabeth L
%A Bishop, D Timothy
%A Brenner, Hermann
%A Buchanan, Daniel D
%A Burnett-Hartman, Andrea
%A Campbell, Peter T
%A Casey, Graham
%A Castellví-Bel, Sergi
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A Figueiredo, Jane C
%A Gallinger, Steven J
%A Giles, Graham G
%A Gruber, Stephen B
%A Gsur, Andrea
%A Gunter, Marc J
%A Hampe, Jochen
%A Hampel, Heather
%A Harrison, Tabitha A
%A Hoffmeister, Michael
%A Hua, Xinwei
%A Huyghe, Jeroen R
%A Jenkins, Mark A
%A Keku, Temitope O
%A Le Marchand, Loic
%A Li, Li
%A Lindblom, Annika
%A Moreno, Victor
%A Newcomb, Polly A
%A Pharoah, Paul D P
%A Platz, Elizabeth A
%A Potter, John D
%A Qu, Conghui
%A Rennert, Gad
%A Schoen, Robert E
%A Slattery, Martha L
%A Song, Mingyang
%A van Duijnhoven, Fränzel J B
%A Van Guelpen, Bethany
%A Vodicka, Pavel
%A Wolk, Alicja
%A Woods, Michael O
%A Wu, Anna H
%A Hayes, Richard B
%A Peters, Ulrike
%A Corley, Douglas A
%A Hsu, Li
%T Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort.
%J Cancer epidemiology, biomarkers & prevention
%V 32
%N 3
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2023-00065
%P 353–362
%D 2023
%X Polygenic risk scores (PRS) which summarize individuals' genetic risk profile may enhance targeted colorectal cancer (CRC) screening. A critical step towards clinical implementation is rigorous external validations in large community-based cohorts. This study externally validated a PRS-enhanced CRC risk model comprising 140 known CRC loci to provide a comprehensive assessment on prediction performance.The model was developed using 20,338 individuals and externally validated in a community-based cohort (n=85,221). We validated predicted 5-year absolute CRC risk, including calibration using expected-to-observed case ratios (E/O) and calibration plots, and discriminatory accuracy using time-dependent AUC. The PRS-related improvement in AUC, sensitivity and specificity were assessed in individuals of age 45-74 years (screening-eligible age group) and 40-49 years with no endoscopy history (younger-age group).In European-ancestral individuals, the predicted 5-year risk calibrated well (E/O=1.01 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36622766
%R 10.1158/1055-9965.EPI-22-0817
%U https://inrepo02.dkfz.de/record/186696