TY  - JOUR
AU  - Su, Yu-Ru
AU  - Sakoda, Lori C
AU  - Jeon, Jihyoun
AU  - Thomas, Minta
AU  - Lin, Yi
AU  - Schneider, Jennifer L
AU  - Udaltsova, Natalia
AU  - Lee, Jeffrey K
AU  - Lansdorp-Vogelaar, Iris
AU  - Peterse, Elisabeth F P
AU  - Zauber, Ann G
AU  - Zheng, Jiayin
AU  - Zheng, Yingye
AU  - Hauser, Elizabeth
AU  - Baron, John A
AU  - Barry, Elizabeth L
AU  - Bishop, D Timothy
AU  - Brenner, Hermann
AU  - Buchanan, Daniel D
AU  - Burnett-Hartman, Andrea
AU  - Campbell, Peter T
AU  - Casey, Graham
AU  - Castellví-Bel, Sergi
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - Figueiredo, Jane C
AU  - Gallinger, Steven J
AU  - Giles, Graham G
AU  - Gruber, Stephen B
AU  - Gsur, Andrea
AU  - Gunter, Marc J
AU  - Hampe, Jochen
AU  - Hampel, Heather
AU  - Harrison, Tabitha A
AU  - Hoffmeister, Michael
AU  - Hua, Xinwei
AU  - Huyghe, Jeroen R
AU  - Jenkins, Mark A
AU  - Keku, Temitope O
AU  - Le Marchand, Loic
AU  - Li, Li
AU  - Lindblom, Annika
AU  - Moreno, Victor
AU  - Newcomb, Polly A
AU  - Pharoah, Paul D P
AU  - Platz, Elizabeth A
AU  - Potter, John D
AU  - Qu, Conghui
AU  - Rennert, Gad
AU  - Schoen, Robert E
AU  - Slattery, Martha L
AU  - Song, Mingyang
AU  - van Duijnhoven, Fränzel J B
AU  - Van Guelpen, Bethany
AU  - Vodicka, Pavel
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Wu, Anna H
AU  - Hayes, Richard B
AU  - Peters, Ulrike
AU  - Corley, Douglas A
AU  - Hsu, Li
TI  - Validation of a genetic-enhanced risk prediction model for colorectal cancer in a large community-based cohort.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 32
IS  - 3
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2023-00065
SP  - 353–362
PY  - 2023
AB  - Polygenic risk scores (PRS) which summarize individuals' genetic risk profile may enhance targeted colorectal cancer (CRC) screening. A critical step towards clinical implementation is rigorous external validations in large community-based cohorts. This study externally validated a PRS-enhanced CRC risk model comprising 140 known CRC loci to provide a comprehensive assessment on prediction performance.The model was developed using 20,338 individuals and externally validated in a community-based cohort (n=85,221). We validated predicted 5-year absolute CRC risk, including calibration using expected-to-observed case ratios (E/O) and calibration plots, and discriminatory accuracy using time-dependent AUC. The PRS-related improvement in AUC, sensitivity and specificity were assessed in individuals of age 45-74 years (screening-eligible age group) and 40-49 years with no endoscopy history (younger-age group).In European-ancestral individuals, the predicted 5-year risk calibrated well (E/O=1.01 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:36622766
DO  - DOI:10.1158/1055-9965.EPI-22-0817
UR  - https://inrepo02.dkfz.de/record/186696
ER  -