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@ARTICLE{Heiss:186715,
      author       = {R. Heiss and M.-A. Weber and E. Balbach and R. Schmitt and
                      C. Rehnitz and A. Laqmani and A. Sternberg and J. J.
                      Ellermann and A. Nagel$^*$ and M. Ladd$^*$ and M. Englbrecht
                      and A. Arkudas and R. Horch and A. Guermazi and M. Uder and
                      F. W. Roemer},
      title        = {{C}linical {A}pplication of {U}ltrahigh-{F}ield-{S}trength
                      {W}rist {MRI}: {A} {M}ultireader 3-{T} and 7-{T}
                      {C}omparison {S}tudy.},
      journal      = {Radiology},
      volume       = {307},
      number       = {2},
      issn         = {0033-8419},
      address      = {Oak Brook, Ill.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2023-00072},
      pages        = {e220753},
      year         = {2023},
      note         = {2023 Apr;307(2):e220753},
      abstract     = {Background Ultrahigh-field-strength MRI at 7 T may permit
                      superior visualization of noninflammatory wrist pathologic
                      conditions, particularly due to its high signal-to-noise
                      ratio compared with the clinical standard of 3 T, but direct
                      comparison studies are lacking. Purpose To compare the
                      subjective image quality of 3-T and 7-T
                      ultrahigh-field-strength wrist MRI through semiquantitative
                      scoring of multiple joint tissues in a multireader study.
                      Materials and Methods In this prospective study, healthy
                      controls and participants with chronic wrist pain underwent
                      3-T and 7-T MRI (coronal T1-weighted turbo spin-echo [TSE],
                      coronal fat-suppressed proton-density [PD]-weighted TSE,
                      transversal T2-weighted TSE) on the same day, from July 2018
                      to June 2019. Images were scored by seven musculoskeletal
                      radiologists. The overall image quality, presence of
                      artifacts, homogeneity of fat suppression, and visualization
                      of cartilage, the triangular fibrocartilage complex (TFCC),
                      and scapholunate and lunotriquetral ligaments were
                      semiquantitatively assessed. Pairwise differences between 3
                      T and 7 T were assessed using the Wilcoxon signed-rank test.
                      Interreader reliability was determined using the Fleiss
                      kappa. Results In total, 25 healthy controls (mean age, 25
                      years ± 4 [SD]; 13 women) and 25 participants with chronic
                      wrist pain (mean age, 39 years ± 16; 14 men) were included.
                      Overall image quality (P = .002) and less presence of
                      artifacts at PD-weighted fat-suppressed MRI were superior at
                      7 T. T1- and T2-weighted MRI were superior at 3 T (both P <
                      .001), as was fat suppression (P < .001). Visualization of
                      cartilage was superior at 7 T (P < .001), while
                      visualization of the TFCC (P < .001) and scapholunate (P =
                      .048) and lunotriquetral (P = .04) ligaments was superior at
                      3 T. Interreader reliability showed slight to substantial
                      agreement for the detected pathologic conditions (κ =
                      0.20-0.64). Conclusion A 7-T MRI of the wrist had potential
                      advantages over 3-T MRI, particularly in cartilage
                      assessment. However, superiority was not shown for all
                      parameters; for example, visualization of the triangular
                      fibrocartilage complex and wrist ligaments was superior at 3
                      T. © RSNA, 2023 Supplemental material is available for this
                      article.},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36625744},
      doi          = {10.1148/radiol.220753},
      url          = {https://inrepo02.dkfz.de/record/186715},
}