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@ARTICLE{Jazmati:186751,
      author       = {D. Jazmati and L. Brualla and A. S. Littooij and B. Webber
                      and K. Dieckmann and G. O. Janssens and T. Simon and M. N.
                      Gaze and J. Merta and A. Serrano and S. Dietzsch and P.-H.
                      Kramer and J. Wulff and T. Boterberg and B. Timmermann$^*$},
      title        = {{O}vercoming inter-observer planning variability in target
                      volume contouring and dose planning for high-risk
                      neuroblastoma - an international multicenter effort of the
                      {SIOPEN} {R}adiotherapy {C}ommittee.},
      journal      = {Radiotherapy and oncology},
      volume       = {181},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-00095},
      pages        = {109464},
      year         = {2023},
      abstract     = {To establish an international quality standard for
                      contouring and planning for high-risk neuroblastoma within
                      the prospective High-Risk Neuroblastoma Study 2 of
                      SIOP-Europe-Neuroblastoma (SIOPEN HR-NBL2), which includes a
                      randomized question on dose escalation for residual
                      disease.Data on four patients with high-risk neuroblastoma
                      were selected and distributed to the radiotherapy committee
                      of the HR-NBL2 study for independent contouring and
                      planning. Differences in contouring were analyzed using
                      apparent and kappa-corrected agreement. Plans were analyzed
                      regarding the dose-volume histogram metrics. Results were
                      discussed among experts and agreement was
                      obtained.Substantial agreement was found for contouring of
                      the heart (0.64), liver (0.70), left lung (0.74), and right
                      lung (0.74). For contouring of the gastrointestinal tract
                      (0.54), left kidney (0.60), and right kidney (0.59) moderate
                      agreement was obtained. For target volume delineation,
                      agreement for preoperative tumour extent was moderate
                      (0.42), for CTV fair (0.35) and only low (0.06) for residual
                      tumour, respectively. The dose planning strategies appeared
                      to be relatively homogeneous among all experts.Considerable
                      variability was found for the delineation of target volumes,
                      particularly the boost volume, whereas the contouring of the
                      organs at risk and the planning strategy were reasonably
                      consistent. In order to obtain reliable results from the
                      randomized HR-NBL2 trial, standardization of target volume
                      delineation based on adequate imaging is crucial.},
      keywords     = {Childhood cancer (Other) / Guideline (Other) /
                      Neuroblastoma (Other) / SIOPEN (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36640946},
      doi          = {10.1016/j.radonc.2023.109464},
      url          = {https://inrepo02.dkfz.de/record/186751},
}