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000186779 041__ $$aEnglish
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000186779 1001_ $$aUgai, Tomotaka$$b0
000186779 245__ $$aPrognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.
000186779 260__ $$aTokyo$$bSpringer$$c2023
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000186779 500__ $$a2023 Mar;58(3):229-245
000186779 520__ $$aThe pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those related to microbiota, inflammation, metabolism, and epigenetics, which may change along colorectal segments. We hypothesized that the prognostic association of colon cancer location might differ by tumor molecular characteristics.Utilizing a consortium dataset of 13,101 colorectal cancer cases, including 2994 early-onset cases, we conducted survival analyses of detailed tumor location stratified by statuses of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF oncogenic mutation.There was a statistically significant trend for better colon cancer-specific survival in relation to tumor location from the cecum to sigmoid colon (Ptrend = 0.002), excluding the rectum. The prognostic association of colon location differed by MSI status (Pinteraction = 0.001). Non-MSI-high tumors exhibited the cecum-to-sigmoid trend for better colon cancer-specific survival [Ptrend < 0.001; multivariable hazard ratio (HR) for the sigmoid colon (vs. cecum), 0.80; 95% confidence interval (CI) 0.70-0.92], whereas MSI-high tumors demonstrated a suggestive cecum-to-sigmoid trend for worse survival (Ptrend = 0.020; the corresponding HR, 2.13; 95% CI 1.15-3.92). The prognostic association of colon tumor location also differed by CIMP status (Pinteraction = 0.003) but not significantly by age, stage, or other features. Furthermore, MSI-high status was a favorable prognostic indicator in all stages.Both detailed colonic location and tumor molecular features need to be accounted for colon cancer prognostication to advance precision medicine. Our study indicates the important role of large-scale studies to robustly examine detailed colonic subsites in molecular oncology research.
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000186779 650_7 $$2Other$$aBiogeography
000186779 650_7 $$2Other$$aEpigenetics
000186779 650_7 $$2Other$$aMismatch repair
000186779 650_7 $$2Other$$aMolecular pathological epidemiology
000186779 650_7 $$2Other$$aYoung-onset cancer
000186779 7001_ $$aAkimoto, Naohiko$$b1
000186779 7001_ $$aHaruki, Koichiro$$b2
000186779 7001_ $$aHarrison, Tabitha A$$b3
000186779 7001_ $$aCao, Yin$$b4
000186779 7001_ $$aQu, Conghui$$b5
000186779 7001_ $$aChan, Andrew T$$b6
000186779 7001_ $$aCampbell, Peter T$$b7
000186779 7001_ $$aBerndt, Sonja I$$b8
000186779 7001_ $$aBuchanan, Daniel D$$b9
000186779 7001_ $$aCross, Amanda J$$b10
000186779 7001_ $$aDiergaarde, Brenda$$b11
000186779 7001_ $$aGallinger, Steven J$$b12
000186779 7001_ $$aGunter, Marc J$$b13
000186779 7001_ $$aHarlid, Sophia$$b14
000186779 7001_ $$aHidaka, Akihisa$$b15
000186779 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b16$$udkfz
000186779 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b17$$udkfz
000186779 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b18$$udkfz
000186779 7001_ $$aHsu, Li$$b19
000186779 7001_ $$aJenkins, Mark A$$b20
000186779 7001_ $$aLin, Yi$$b21
000186779 7001_ $$aMilne, Roger L$$b22
000186779 7001_ $$aMoreno, Victor$$b23
000186779 7001_ $$aNewcomb, Polly A$$b24
000186779 7001_ $$aNishihara, Reiko$$b25
000186779 7001_ $$aObon-Santacana, Mireia$$b26
000186779 7001_ $$aPai, Rish K$$b27
000186779 7001_ $$aSakoda, Lori C$$b28
000186779 7001_ $$aSchoen, Robert E$$b29
000186779 7001_ $$aSlattery, Martha L$$b30
000186779 7001_ $$aSun, Wei$$b31
000186779 7001_ $$0P:(DE-He78)6e02c183f41e45a5867dec393fb4616a$$aAmitay, Efrat$$b32
000186779 7001_ $$0P:(DE-He78)9b2a61b2abe4a64ca23b6783b7c4fe63$$aAlwers, Elizabeth$$b33$$udkfz
000186779 7001_ $$aThibodeau, Stephen N$$b34
000186779 7001_ $$aToland, Amanda E$$b35
000186779 7001_ $$aVan Guelpen, Bethany$$b36
000186779 7001_ $$aZaidi, Syed H$$b37
000186779 7001_ $$aPotter, John D$$b38
000186779 7001_ $$aMeyerhardt, Jeffrey A$$b39
000186779 7001_ $$aGiannakis, Marios$$b40
000186779 7001_ $$aSong, Mingyang$$b41
000186779 7001_ $$aNowak, Jonathan A$$b42
000186779 7001_ $$aPeters, Ulrike$$b43
000186779 7001_ $$aPhipps, Amanda I$$b44
000186779 7001_ $$00000-0002-3909-2323$$aOgino, Shuji$$b45
000186779 773__ $$0PERI:(DE-600)1473159-9$$a10.1007/s00535-023-01955-2$$n3$$p229-245$$tJournal of gastroenterology$$v58$$x0944-1174$$y2023
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