% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{DaoTrong:186780,
      author       = {P. Dao Trong and M. Gluszak and D. Reuss$^*$ and A. von
                      Deimling$^*$ and A. Wick and L. König and J. Debus and C.
                      Herold-Mende and A. Unterberg and C. Jungk},
      title        = {{I}socitrate-dehydrogenase-mutant lower grade glioma in
                      elderly patients: treatment and outcome in a molecularly
                      characterized contemporary cohort.},
      journal      = {Journal of neuro-oncology},
      volume       = {161},
      number       = {3},
      issn         = {0167-594x},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DKFZ-2023-00108},
      pages        = {605-615},
      year         = {2023},
      note         = {2023 Feb;161(3):605-615},
      abstract     = {Lower-grade glioma (LGG) is rare among patients above the
                      age of 60 ('elderly'). Previous studies reported poor
                      outcome, likely due to the inclusion of isocitrate
                      dehydrogenase (IDH) wildtype astrocytomas and advocated
                      defensive surgical and adjuvant treatment. This study set
                      out to question this paradigm analyzing a contemporary
                      cohort of patients with IDH mutant astrocytoma and
                      oligodendroglioma WHO grade 2 and 3.Elderly patients treated
                      in our department for a supratentorial, hemispheric LGG
                      between 2009 and 2019 were retrospectively analyzed for
                      patient-, tumor- and treatment-related factors and
                      progression-free survival (PFS) and compared to patients
                      aged under 60. Inclusion required the availability of
                      subtype-defining molecular data and pre- and post-operative
                      tumor volumes.207 patients were included, among those 21
                      elderlies $(10\%).$ PFS was comparable between elderly and
                      younger patients (46 vs. 54 months; p = 0.634).
                      Oligodendroglioma was more common in the elderly $(76\%$ vs.
                      $46\%;$ p = 0.011). Most patients underwent tumor resection
                      (elderly: $81\%$ vs. younger: $91\%;$ p = 0.246) yielding
                      comparable residual tumor volumes (elderly: 7.8 cm3;
                      younger: 4.1 cm3; p = 0.137). Adjuvant treatment was
                      administered in $76\%$ of elderly and $61\%$ of younger
                      patients (p = 0.163). Uni- and multi-variate survival
                      analyses identified a tumor crossing the midline, surgical
                      strategy, and pre- and post-operative tumor volumes as
                      prognostic factors.Elderly patients constitute a small
                      fraction of molecularly characterized LGGs. In contrast to
                      previous reports, favorable surgical and survival outcomes
                      were achieved in our series comparable to those of younger
                      patients. Thus, intensified treatment including maximal safe
                      resection should be advocated in elderly patients whenever
                      feasible.},
      keywords     = {Elderly (Other) / Isocitrate dehydrogenase mutant glioma
                      (Other) / Lower grade glioma (Other) / WHO classification
                      (Other)},
      cin          = {B300 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B300-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36648586},
      doi          = {10.1007/s11060-022-04230-1},
      url          = {https://inrepo02.dkfz.de/record/186780},
}