TY  - JOUR
AU  - Broséus, Julien
AU  - Hergalant, Sébastien
AU  - Vogt, Julia
AU  - Tausch, Eugen
AU  - Kreuz, Markus
AU  - Mottok, Anja
AU  - Schneider, Christof
AU  - Dartigeas, Caroline
AU  - Roos-Weil, Damien
AU  - Quinquenel, Anne
AU  - Moulin, Charline
AU  - Ott, German
AU  - Blanchet, Odile
AU  - Tomowiak, Cécile
AU  - Lazarian, Grégory
AU  - Rouyer, Pierre
AU  - Chteinberg, Emil
AU  - Bernhart, Stephan H
AU  - Tournilhac, Olivier
AU  - Gauchotte, Guillaume
AU  - Lomazzi, Sandra
AU  - Chapiro, Elise
AU  - Nguyen-Khac, Florence
AU  - Chery, Céline
AU  - Davi, Frédéric
AU  - Hunault, Mathilde
AU  - Houlgatte, Rémi
AU  - Rosenwald, Andreas
AU  - Delmer, Alain
AU  - Meyre, David
AU  - Béné, Marie-Christine
AU  - Thieblemont, Catherine
AU  - Lichter, Peter
AU  - Ammerpohl, Ole
AU  - Guéant, Jean-Louis
AU  - Guièze, Romain
AU  - Martin-Subero, José Ignacio
AU  - Cymbalista, Florence
AU  - Feugier, Pierre
AU  - Siebert, Reiner
AU  - Stilgenbauer, Stephan
TI  - Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis.
JO  - Nature Communications
VL  - 14
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DKFZ-2023-00124
SP  - 309
PY  - 2023
AB  - Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). We characterize 58 primary human RS samples by genome-wide DNA methylation and whole-transcriptome profiling. Our comprehensive approach determines RS DNA methylation profile and unravels a CLL epigenetic imprint, allowing CLL-RS clonal relationship assessment without the need of the initial CLL tumor DNA. DNA methylation- and transcriptomic-based classifiers were developed, and testing on landmark DLBCL datasets identifies a poor-prognosis, activated B-cell-like DLBCL subset in 111/1772 samples. The classification robustly identifies phenotypes very similar to RS with a specific genomic profile, accounting for 4.3-8.3
LB  - PUB:(DE-HGF)16
C6  - pmid:36658118
DO  - DOI:10.1038/s41467-022-34642-6
UR  - https://inrepo02.dkfz.de/record/210400
ER  -