TY  - JOUR
AU  - Crivello, Pietro
AU  - Arrieta-Bolaños, Esteban
AU  - He, Meilun
AU  - Wang, Tao
AU  - Fingerson, Stephanie
AU  - Gadalla, Shahinaz M
AU  - Paczesny, Sophie
AU  - Marsh, Steven G E
AU  - Lee, Stephanie J
AU  - Spellman, Stephen R
AU  - Bolon, Yung-Tsi
AU  - Fleischhauer, Katharina
TI  - Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation.
JO  - Journal of clinical oncology
VL  - 41
IS  - 13
SN  - 0732-183X
CY  - Alexandria, Va.
PB  - American Society of Clinical Oncology
M1  - DKFZ-2023-00128
SP  - 2416-2427
PY  - 2023
N1  - 2023 May 1;41(13):2416-2427
AB  - Immunopeptidome divergence between mismatched HLA-DP is a determinant of T-cell alloreactivity and clinical tolerability after fully HLA-A, -B, -C, -DRB1, -DQB1 matched unrelated donor hematopoietic cell transplantation (UD-HCT). Here, we tested this concept in HLA-A, -B, and -C disparities after single class I HLA-mismatched UD-HCT.We studied 2,391 single class I HLA-mismatched and 14,426 fully HLA-matched UD-HCT performed between 2008 and 2018 for acute leukemia or myelodysplastic syndromes. Hierarchical clustering of experimentally determined peptide-binding motifs (PBM) was used as a proxy for immunopeptidome divergence of HLA-A, -B, or -C disparities, allowing us to classify 1,629/2,391 (68.1
LB  - PUB:(DE-HGF)16
C6  - pmid:36669145
DO  - DOI:10.1200/JCO.22.01229
UR  - https://inrepo02.dkfz.de/record/212409
ER  -