TY  - JOUR
AU  - Chmielewski, Witold X
AU  - Walbrodt, Sebastian
AU  - Rauschenbach, Laurèl
AU  - Chihi, Mehdi
AU  - Gembruch, Oliver
AU  - Darkwah Oppong, Marvin
AU  - Schroer, Sebastian
AU  - Wrede, Karsten H
AU  - Dammann, Philipp
AU  - Jabbarli, Ramazan
AU  - Kreitschmann-Andermahr, Ilonka
AU  - Sato, Taku
AU  - Unger, Nicole
AU  - Mattheis, Stefan
AU  - Sure, Ulrich
AU  - Ahmadipour, Yahya
TI  - Pre-Surgery Patient Health Contributes to Aggravated Sino-Nasal Outcome and Quality of Life after Pituitary Adenomectomy.
JO  - Medicina
VL  - 59
IS  - 1
SN  - 1010-660X
CY  - Kaunas
PB  - Kaunas Univ. of Medicine
M1  - DKFZ-2023-00137
SP  - 127
PY  - 2023
AB  - Objectives: The transphenoidal bi-nostril endoscopic resection of pituitary adenomas is regarded as a minimally invasive treatment nowadays. However, sino-nasal outcome and health-related quality of life (HRQoL) might still be impaired after the adenomectomy, depending on patients' prior medical history and health status. A systematic postoperative comparison is required to assess differences in perceived sino-nasal outcome and HRQoL. Methods: In this single-center observational study, we collected data from 81 patients, operated between August 2016 and August 2021, at a 3-6-month follow-up after adenomectomy. We employed the sino-nasal outcome test for neurosurgery (SNOT-NC) and the HRQoL inventory Short Form (SF)-36 to compare sino-nasal and HRQoL outcome in patients with or without allergies, previous nose surgeries, presence of pain, snoring, sleep apnea, usage of continuous positive airway pressure (cpap), and nose drop usage. Results: At the 3-6-month follow-up, patients with previous nasal surgery showed overall reduced subjective sino-nasal health, increased nasal and ear/head discomfort, increased visual impairment, and decreased psychological HRQoL (all p ≤ 0.026) after pituitary adenomectomy. Patients with pain before surgery showed a trend-level aggravated physical HRQoL (p = 0.084). Conclusion: Our data show that patients with previous nasal surgery have an increased risk of an aggravated sino-nasal and HRQoL outcome after pituitary adenomectomy. These patients should be thoroughly informed about potential consequences to induce realistic patient expectations. Moreover, the study shows that patients with moderately severe allergies, snoring, and sleep apnea (± cpap) usually do not have to expect a worsened sino-nasal health and HRQoL outcome.
KW  - adenomectomy (Other)
KW  - health-related quality of life (Other)
KW  - pituitary adenoma (Other)
KW  - pre-surgery patient health (Other)
KW  - sino-nasal health (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36676751
DO  - DOI:10.3390/medicina59010127
UR  - https://inrepo02.dkfz.de/record/212418
ER  -