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@ARTICLE{Chmielewski:212418,
      author       = {W. X. Chmielewski$^*$ and S. Walbrodt$^*$ and L.
                      Rauschenbach$^*$ and M. Chihi$^*$ and O. Gembruch$^*$ and M.
                      Darkwah Oppong$^*$ and S. Schroer$^*$ and K. H. Wrede$^*$
                      and P. Dammann$^*$ and R. Jabbarli$^*$ and I.
                      Kreitschmann-Andermahr$^*$ and T. Sato$^*$ and N. Unger and
                      S. Mattheis and U. Sure$^*$ and Y. Ahmadipour$^*$},
      title        = {{P}re-{S}urgery {P}atient {H}ealth {C}ontributes to
                      {A}ggravated {S}ino-{N}asal {O}utcome and {Q}uality of
                      {L}ife after {P}ituitary {A}denomectomy.},
      journal      = {Medicina},
      volume       = {59},
      number       = {1},
      issn         = {1010-660X},
      address      = {Kaunas},
      publisher    = {Kaunas Univ. of Medicine},
      reportid     = {DKFZ-2023-00137},
      pages        = {127},
      year         = {2023},
      abstract     = {Objectives: The transphenoidal bi-nostril endoscopic
                      resection of pituitary adenomas is regarded as a minimally
                      invasive treatment nowadays. However, sino-nasal outcome and
                      health-related quality of life (HRQoL) might still be
                      impaired after the adenomectomy, depending on patients'
                      prior medical history and health status. A systematic
                      postoperative comparison is required to assess differences
                      in perceived sino-nasal outcome and HRQoL. Methods: In this
                      single-center observational study, we collected data from 81
                      patients, operated between August 2016 and August 2021, at a
                      3-6-month follow-up after adenomectomy. We employed the
                      sino-nasal outcome test for neurosurgery (SNOT-NC) and the
                      HRQoL inventory Short Form (SF)-36 to compare sino-nasal and
                      HRQoL outcome in patients with or without allergies,
                      previous nose surgeries, presence of pain, snoring, sleep
                      apnea, usage of continuous positive airway pressure (cpap),
                      and nose drop usage. Results: At the 3-6-month follow-up,
                      patients with previous nasal surgery showed overall reduced
                      subjective sino-nasal health, increased nasal and ear/head
                      discomfort, increased visual impairment, and decreased
                      psychological HRQoL (all p ≤ 0.026) after pituitary
                      adenomectomy. Patients with pain before surgery showed a
                      trend-level aggravated physical HRQoL (p = 0.084).
                      Conclusion: Our data show that patients with previous nasal
                      surgery have an increased risk of an aggravated sino-nasal
                      and HRQoL outcome after pituitary adenomectomy. These
                      patients should be thoroughly informed about potential
                      consequences to induce realistic patient expectations.
                      Moreover, the study shows that patients with moderately
                      severe allergies, snoring, and sleep apnea (± cpap) usually
                      do not have to expect a worsened sino-nasal health and HRQoL
                      outcome.},
      keywords     = {adenomectomy (Other) / health-related quality of life
                      (Other) / pituitary adenoma (Other) / pre-surgery patient
                      health (Other) / sino-nasal health (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36676751},
      doi          = {10.3390/medicina59010127},
      url          = {https://inrepo02.dkfz.de/record/212418},
}