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@ARTICLE{Schpe:212421,
      author       = {P. C. Schöpe and V. Zinnow and M. A. Ishfaq and J. Smith
                      and P. Herrmann and R. H. Shoemaker and W. Walther$^*$ and
                      U. Stein$^*$},
      title        = {{C}antharidin and {I}ts {A}nalogue {N}orcantharidin
                      {I}nhibit {M}etastasis-{I}nducing {G}enes {S}100{A}4 and
                      {MACC}1.},
      journal      = {International journal of molecular sciences},
      volume       = {24},
      number       = {2},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DKFZ-2023-00140},
      pages        = {1179},
      year         = {2023},
      abstract     = {Colorectal cancer (CRC) is the third most prevalent and
                      second deadliest cancer worldwide. In addition, metastasis
                      directly causes up to $90\%$ of all CRC deaths, highlighting
                      the metastatic burden of the disease. Biomarkers such as
                      S100A4 and MACC1 aid in identifying patients with a high
                      risk of metastasis formation. High expression of S100A4 or
                      MACC1 and to a greater extent the combination of both
                      biomarkers is a predictor for metastasis and poor patient
                      survival in CRC. MACC1 is a tumor-initiating and
                      metastasis-promoting oncogene, whereas S100A4 has not been
                      shown to initiate tumor formation but can, nevertheless,
                      promote malignant tumor growth and metastasis formation.
                      Cantharidin is a natural drug extracted from various blister
                      beetle species, and its demethylated analogue norcantharidin
                      has been shown in several studies to have an anti-cancer and
                      anti-metastatic effect in different cancer entities such as
                      CRC, breast cancer, and lung cancer. The impact of the
                      natural compound cantharidin and norcantharidin on S100A4
                      and MACC1 gene expression, cancer cell migration, motility,
                      and colony formation in vitro was tested. Here, for the
                      first time, we have demonstrated that cantharidin and
                      norcantharidin are transcriptional inhibitors of S100A4 and
                      MACC1 mRNA expression, protein expression, and motility in
                      CRC cells. Our results clearly indicate that cantharidin
                      and, to a lesser extent, its analogue norcantharidin are
                      promising compounds for efficient anti-metastatic therapy
                      targeting the metastasis-inducing genes S100A4 and MACC1 for
                      personalized medicine for cancer patients.},
      keywords     = {MACC1 (Other) / S100A4 (Other) / cantharidin (Other) /
                      colorectal cancer (Other) / metastasis (Other) /
                      norcantharidin (Other)},
      cin          = {BE01},
      ddc          = {540},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36674695},
      doi          = {10.3390/ijms24021179},
      url          = {https://inrepo02.dkfz.de/record/212421},
}