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@ARTICLE{Roner:212427,
      author       = {F. Roßner and B. V. Sinn and D. Horst$^*$},
      title        = {{P}athology of {C}ombined {H}epatocellular
                      {C}arcinoma-{C}holangiocarcinoma: {A}n {U}pdate.},
      journal      = {Cancers},
      volume       = {15},
      number       = {2},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00146},
      pages        = {494},
      year         = {2023},
      abstract     = {Combined hepatocellular carcinoma-cholangiocarcinoma
                      (cHCC-CCA) is a rare primary liver cancer that is composed
                      of both hepatocellular and cholangiocellular differentiated
                      cells. It is slightly more common in men and among Asian and
                      Pacific islanders. Overall, risk factors are similar to
                      classic risk factors of hepatocellular carcinoma (HCC). The
                      classification has significantly evolved over time. The last
                      WHO classification (2019) mainly emphasized diagnosis on
                      morphological basis with routine stainings, discarded
                      previously recognized classifications with carcinomas with
                      stem cell features, introduced intermediate cell carcinoma
                      as a specific subtype and considered cholangiolocarcinoma as
                      a subtype of cholangiocellular carcinoma.
                      Immunohistochemical markers may be applied for further
                      specification but have limited value for diagnosis. Recent
                      discoveries in molecular pathway regulation may pioneer new
                      therapeutic approaches for this poor prognostic and
                      challenging diagnosis.},
      subtyp        = {Review Article},
      keywords     = {cHCC-CCA (Other) / cholangiocarcinoma (Other) / combined
                      hepatocellular and cholangiocellular carcinoma (Other) /
                      hepatocellular carcinoma (Other) / hippo signaling (Other) /
                      mixed carcinoma (Other) / progenitor cells (Other) / stem
                      cells (Other) / wnt signaling (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36672443},
      pmc          = {pmc:PMC9856551},
      doi          = {10.3390/cancers15020494},
      url          = {https://inrepo02.dkfz.de/record/212427},
}