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@ARTICLE{Ratiner:212429,
      author       = {K. Ratiner and T. Fachler-Sharp and E. Elinav$^*$},
      title        = {{S}mall {I}ntestinal {M}icrobiota {O}scillations, {H}ost
                      {E}ffects and {R}egulation-{A} {Z}oom into {T}hree {K}ey
                      {E}ffector {M}olecules.},
      journal      = {Biology},
      volume       = {12},
      number       = {1},
      issn         = {2079-7737},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-00148},
      pages        = {142},
      year         = {2023},
      note         = {#LA:F220#},
      abstract     = {The gut microbiota features a unique diurnal rhythmicity
                      which contributes to modulation of host physiology and
                      homeostasis. The composition and activity of the microbiota
                      and its secreted molecules influence the intestinal milieu
                      and neighboring organs, such as the liver. Multiple
                      immune-related molecules have been linked to the diurnal
                      microbiota-host interaction, including Reg3γ, IgA, and
                      MHCII, which are secreted or expressed on the gut surface
                      and directly interact with intestinal bacteria. These
                      molecules are also strongly influenced by dietary patterns,
                      such as high-fat diet and time-restricted feeding, which are
                      already known to modulate microbial rhythms and peripheral
                      clocks. Herein, we use Reg3γ, IgA, and MHCII as test cases
                      to highlight the divergent effects mediated by the diurnal
                      activity of the gut microbiota and their downstream host
                      effects. We further highlight current challenges and
                      conflicts, remaining questions, and perspectives toward a
                      holistic understanding of the microbiome's impacts on
                      circadian human behavior.},
      subtyp        = {Review Article},
      keywords     = {circadian clock (Other) / dietary timing (Other) /
                      microbiome (Other) / segmented filamentous bacteria (Other)
                      / small intestine (Other)},
      cin          = {F220},
      ddc          = {570},
      cid          = {I:(DE-He78)F220-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36671834},
      pmc          = {pmc:PMC9855434},
      doi          = {10.3390/biology12010142},
      url          = {https://inrepo02.dkfz.de/record/212429},
}