TY  - JOUR
AU  - Bengel, Philipp
AU  - Elkenani, Manar
AU  - Beuthner, Bo E
AU  - Pietzner, Maik
AU  - Mohamed, Belal A
AU  - Pollok-Kopp, Beatrix
AU  - Krätzner, Ralph
AU  - Toischer, Karl
AU  - Puls, Miriam
AU  - Fischer, Andreas
AU  - Binder, Lutz
AU  - Hasenfuß, Gerd
AU  - Schnelle, Moritz
TI  - Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis.
JO  - Biomolecules
VL  - 13
IS  - 1
SN  - 2218-273X
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-00149
SP  - 95
PY  - 2023
AB  - Severe aortic stenosis (AS) is a common pathological condition in an ageing population imposing significant morbidity and mortality. Based on distinct hemodynamic features, i.e., ejection fraction (EF), transvalvular gradient and stroke volume, four different AS subtypes can be distinguished: (i) normal EF and high gradient, (ii) reduced EF and high gradient, (iii) reduced EF and low gradient, and (iv) normal EF and low gradient. These subtypes differ with respect to pathophysiological mechanisms, cardiac remodeling, and prognosis. However, little is known about metabolic changes in these different hemodynamic conditions of AS. Thus, we carried out metabolomic analyses in serum samples of 40 AS patients (n = 10 per subtype) and 10 healthy blood donors (controls) using ultrahigh-performance liquid chromatography-tandem mass spectroscopy. A total of 1293 biochemicals could be identified. Principal component analysis revealed different metabolic profiles in all of the subgroups of AS (All-AS) vs. controls. Out of the determined biochemicals, 48
KW  - heart failure (Other)
KW  - hemodynamic subgroups (Other)
KW  - metabolic remodeling (Other)
KW  - metabolomics (Other)
KW  - severe aortic valve stenosis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36671480
C2  - pmc:PMC9855798
DO  - DOI:10.3390/biom13010095
UR  - https://inrepo02.dkfz.de/record/212430
ER  -