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@ARTICLE{Stocker:212457,
      author       = {H. Stocker$^*$ and L. Beyer and K. Trares$^*$ and L. Perna
                      and D. Rujescu and B. Holleczek and K. Beyreuther and K.
                      Gerwert and B. Schöttker$^*$ and H. Brenner$^*$},
      title        = {{A}ssociation of {K}idney {F}unction {W}ith {D}evelopment
                      of {A}lzheimer {D}isease and {O}ther {D}ementias and
                      {D}ementia-{R}elated {B}lood {B}iomarkers.},
      journal      = {JAMA network open},
      volume       = {6},
      number       = {1},
      issn         = {2574-3805},
      address      = {Chicago, Ill.},
      publisher    = {American Medical Association},
      reportid     = {DKFZ-2023-00174},
      pages        = {e2252387 -},
      year         = {2023},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Previous research has suggested an association of kidney
                      function with risk of Alzheimer disease (AD) or other
                      dementias and dementia-related blood biomarkers, but a
                      distinct association remains unclear.To evaluate the
                      association of kidney function with risk of diagnosis of
                      incident AD or dementia within 17 years and with the blood
                      biomarkers neurofilament light (NfL), phosphorylated tau181
                      (p-tau181), and glial fibrillary acidic protein (GFAP).In
                      this prospective, population-based cohort study and nested
                      case-control study, 9940 participants in Germany were
                      enrolled between 2000 and 2002 by their general
                      practitioners and followed up for up to 17 years.
                      Participants were included if information on dementia status
                      and creatinine/cystatin C measurements were available. A
                      subsample of participants additionally had measurements of
                      NfL, p-tau181, and GFAP obtained from blood samples.
                      Statistical analysis was performed from January 3 to
                      November 25, 2022.Impaired kidney function, based on
                      estimated glomerular filtration rate less than 60
                      mL/min/1.73 m2 according to the 2021 Chronic Kidney Disease
                      Epidemiology Collaboration creatinine-cystatin C
                      equation.All-cause dementia, AD, and vascular dementia
                      diagnosis, as well as log-transformed levels of NfL,
                      p-tau181, and GFAP in blood.Of 6256 participants (3402 women
                      $[54.4\%];$ mean [SD] age at baseline, 61.7 [6.6] years),
                      510 received an all-cause dementia diagnosis within 17 years
                      of baseline. The dementia-related blood biomarker nested
                      case-control sample included 766 participants. After
                      adjusting for age and sex, impaired kidney function at
                      baseline was not associated with a higher risk of all-cause
                      dementia (hazard ratio [HR], 0.95; $95\%$ CI, 0.69-1.29), AD
                      (HR, 0.94; $95\%$ CI, 0.55-1.63), or vascular dementia
                      diagnosis (HR, 1.06; $95\%$ CI, 0.65-1.70) within 17 years.
                      In the cross-sectional analysis, after adjusting for age and
                      sex, impaired kidney function was significantly associated
                      with NfL and p-tau181 levels in blood (NfL: β = 0.47 and P
                      < .001; p-tau181: β = 0.21 and P = .003). After adjusting
                      for age and sex, significant associations with GFAP levels
                      were evident only among men (men: β = 0.31 and P = .006;
                      women: β = -0.12 and P = .11).In this population-based
                      study of community-dwelling adults, reduced kidney function
                      was associated with increased levels of dementia-related
                      blood biomarkers but not increased dementia risk. Kidney
                      function might influence the accuracy of dementia-related
                      blood biomarkers and should be considered in clinical
                      translation.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36692879},
      doi          = {10.1001/jamanetworkopen.2022.52387},
      url          = {https://inrepo02.dkfz.de/record/212457},
}