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@ARTICLE{Pecori:212490,
      author       = {R. Pecori$^*$ and I. Chillón and C. Lo Giudice and A.
                      Arnold$^*$ and S. Wüst$^*$ and M. Binder$^*$ and M. Marcia
                      and E. Picardi and F. Papavasiliou$^*$},
      title        = {{ADAR} {RNA} editing on antisense {RNA}s results in
                      apparent {U}-to-{C} base changes on overlapping sense
                      transcripts.},
      journal      = {Frontiers in cell and developmental biology},
      volume       = {10},
      issn         = {2296-634X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2023-00191},
      pages        = {1080626},
      year         = {2023},
      note         = {#EA:D150#LA:D150# / HI-TRON},
      abstract     = {Despite hundreds of RNA modifications described to date,
                      only RNA editing results in a change in the nucleotide
                      sequence of RNA molecules compared to the genome. In
                      mammals, two kinds of RNA editing have been described so
                      far, adenosine to inosine (A-to-I) and cytidine to uridine
                      (C-to-U) editing. Recent improvements in RNA sequencing
                      technologies have led to the discovery of a continuously
                      growing number of editing sites. These methods are powerful
                      but not error-free, making routine validation of
                      newly-described editing sites necessary. During one of these
                      validations on DDX58 mRNA, along with A-to-I RNA editing
                      sites, we encountered putative U-to-C editing. These U-to-C
                      edits were present in several cell lines and appeared
                      regulated in response to specific environmental stimuli. The
                      same findings were also observed for the human long
                      intergenic non-coding RNA p21 (hLincRNA-p21). A more
                      in-depth analysis revealed that putative U-to-C edits result
                      from A-to-I editing on overlapping antisense RNAs that are
                      transcribed from the same loci. Such editing events,
                      occurring on overlapping genes transcribed in opposite
                      directions, have recently been demonstrated to be
                      immunogenic and have been linked with autoimmune and
                      immune-related diseases. Our findings, also confirmed by
                      deep transcriptome data, demonstrate that such loci can be
                      recognized simply through the presence of A-to-I and U-to-C
                      mismatches within the same locus, reflective A-to-I editing
                      both in the sense-oriented transcript and in the cis-natural
                      antisense transcript (cis-NAT), implying that such clusters
                      could be a mark of functionally relevant ADAR1 editing
                      events.},
      keywords     = {ADAR (Other) / DDX58/RIG-I (Other) / LINC-P21 (Other) /
                      MultiEditR (Other) / RNA editing (Other) / U-to-C (Other)},
      cin          = {D150 / F170},
      ddc          = {570},
      cid          = {I:(DE-He78)D150-20160331 / I:(DE-He78)F170-20160331},
      pnm          = {314 - Immunologie und Krebs (POF4-314)},
      pid          = {G:(DE-HGF)POF4-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36684421},
      pmc          = {pmc:PMC9852825},
      doi          = {10.3389/fcell.2022.1080626},
      url          = {https://inrepo02.dkfz.de/record/212490},
}