% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Sachpekidis:212535,
      author       = {C. Sachpekidis and A. Kopp-Schneider$^*$ and V. Sachpekidis
                      and E. Moralidis},
      title        = {{A} comparative assessment of intra- and inter- observer
                      repeatability of three widely used software packages for the
                      quantification of defect size in stress myocardial perfusion
                      scintigraphy.},
      journal      = {Hellenic journal of nuclear medicine},
      volume       = {25},
      number       = {3},
      issn         = {1108-1430},
      address      = {Thessaloniki},
      reportid     = {DKFZ-2023-00220},
      pages        = {274-284},
      year         = {2022},
      abstract     = {To assess the intra- and inter-observer repeatability of
                      popular software packages for the quantitative determination
                      of abnormality size in stress myocardial perfusion
                      scintigraphy.A total of 182 tomographic stress myocardial
                      perfusion scans were processed in duplicate by an
                      experienced and trainee observer to assess SSSext (summed
                      stress score multiplied by 100/68) and total defect extent
                      (TDE), as $\%$ of the left ventricle, with 4
                      dimension-myocardial (4DM), emory cardiac toolbox (ECTb) and
                      quantitative perfusion SPECT (QPS) packages. The
                      Bland-Altman (B-A) analysis and Lin's concordance
                      correlation coefficient (CCC) were used to assess
                      agreement.In SSSext's intra-observer repeatability, CCC
                      showed substantial agreement for 4DM and QPS, and moderate
                      agreement for ECTb for both observers. In inter-observer
                      repeatability, CCC revealed substantial agreement for 4DM
                      and QPS, and poor agreement for ECTb. Regarding TDE, CCC
                      showed substantial intra-observer repeatability for both
                      operators using all packages, while the inter-observer
                      repeatability was substantial for 4DM and QPS, and moderate
                      for ECTb.In SSSext's intra-observer repeatability for 4DM,
                      ECTb and QPS, the B-A analysis provided (mean±1.96SD of
                      paired measurements) 0.0±4.3, 0.2±7.8, -0.6±7.6 for the
                      experienced physician and 0.2±5.9, 0.0±7.5, -0.5±5.4 for
                      the trainee, respectively; in inter-observer repeatability
                      it provided 0.2±5.4, 0.1±9.6, 0.2±8.1, respectively.
                      Regarding TDE, the B-A values for intra-observer
                      repeatability were 0.1±5.2, 0.1±7.9, 0.1±2.8 for the
                      experienced reader and 0.3±6.6, -0.1±6.4, -0.1±2.4 for
                      the trainee, respectively; in inter-observer agreement the
                      B-A provided 0.6±6.4, -0.2±10.3, -0.1±4.3,
                      respectively.Considerable differences in intra- and inter-
                      observer agreement were noted for the quantitative
                      determination of defect size using widely employed software
                      packages, suggesting limitations in the clinical use of
                      these measurements. Quantitative perfusion SPECT appears
                      preferable, but with no significant advantage over 4DM.
                      There were no significant differences between the
                      observers.},
      keywords     = {Humans / Software / Heart / Tomography, Emission-Computed,
                      Single-Photon: methods / Heart Ventricles / Perfusion
                      Imaging / Reproducibility of Results / Observer Variation},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36507884},
      doi          = { DOI:10.1967/s002449912516 },
      url          = {https://inrepo02.dkfz.de/record/212535},
}