TY  - JOUR
AU  - Eichkorn, Tanja
AU  - Lischalk, Jonathan W
AU  - Stüwe, Cedric
AU  - Tonndorf-Martini, Eric
AU  - Schubert, Kai
AU  - Dinges, Lisa-Antonia
AU  - Regnery, Sebastian
AU  - Bozorgmehr, Farastuk
AU  - König, Laila
AU  - Christopoulos, Petros
AU  - Hörner-Rieber, Juliane
AU  - Adeberg, Sebastian
AU  - Herfarth, Klaus
AU  - Winter, Hauke
AU  - Thomas, Michael
AU  - Rieken, Stefan
AU  - Debus, Jürgen
AU  - El Shafie, Rami A
TI  - High-risk patients with locally advanced non-small cell lung cancer treated with stereotactic body radiation therapy to the peripheral primary combined with conventionally fractionated volumetric arc therapy to the mediastinal lymph nodes.
JO  - Frontiers in oncology
VL  - 12
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - DKFZ-2023-00227
SP  - 1035370
PY  - 2023
AB  - A very narrow therapeutic window exists when delivering curative chemoradiotherapy for inoperable locally advanced non-small cell lung cancer (NSCLC), particularly when large distances exist between areas of gross disease in the thorax. In the present study, we hypothesize that a novel technique of stereotactic body radiation therapy (SBRT) to the primary tumor in combination with volumetric arc therapy (VMAT) to the mediastinal lymph nodes (MLN) is a suitable approach for high-risk patients with large volume geographically distant locally advanced NSCLC.In this single institutional review, we identified high-risk patients treated between 2014 and 2017 with SBRT to the parenchymal lung primary as well as VMAT to the involved MLN using conventional fractionation. Dosimetrically, comparative plans utilizing VMAT conventionally fractionated delivered to both the primary and MLN were analyzed. Clinically, toxicity (CTCAE version 5.0) and oncologic outcomes were analyzed in detail.A total of 21 patients were identified, 86
KW  - dosimetric comparison (Other)
KW  - high-risk patients (Other)
KW  - locally advanced non-small cell lung cancer (NSCLC) (Other)
KW  - peripherally located NSCLC (Other)
KW  - pulmonary toxicity (Other)
KW  - radiation therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36713565
C2  - pmc:PMC9880536
DO  - DOI:10.3389/fonc.2022.1035370
UR  - https://inrepo02.dkfz.de/record/212542
ER  -