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@ARTICLE{Hemminki:212543,
      author       = {K. Hemminki$^*$ and K. Sundquist and J. Sundquist and A.
                      Försti$^*$ and V. Liska and A. Hemminki and X. Li},
      title        = {{A}utoimmune diseases as comorbidities for liver,
                      gallbladder, and biliary duct cancers in {S}weden.},
      journal      = {Cancer},
      volume       = {129},
      number       = {8},
      issn         = {0008-543x},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-00228},
      pages        = {1227-1236},
      year         = {2023},
      note         = {#EA:C020# / Volume129, Issue 8, 15 April 2023, Pages
                      1227-1236},
      abstract     = {Autoimmune diseases are associated with many cancers but
                      there is a lack of population-based studies with different
                      autoimmune diseases that have a long follow-up. This is also
                      true of hepatobiliary cancers, which include hepatocellular
                      cancer (HCC) and rarer entities of gallbladder cancer (GBC),
                      intra- and extrahepatic cholangiocarcinoma (iCCA and eCCA),
                      and ampullary cancer.Diagnostic data on 43 autoimmune
                      diseases were collected from the Swedish Inpatient Register
                      from 1987 to 2018, and cancer data were derived from the
                      national cancer registry from 1997 onward. Relative risks
                      were expressed as standardized incidence ratios (SIRs).In a
                      population of 13.6 million, 1.1 million autoimmune diseases
                      were diagnosed and subsequent hepatobiliary cancer was
                      diagnosed in 3191 patients $(17.2\%$ of cancers). SIRs for
                      HCC were 2.73 (men) and 2.86 (women), 3.74/1.96 for iCCA,
                      2.65/1.37 for GBC, 2.38/1.64 for eCCA, and 1.80/1.85 for
                      ampullary cancer. Significant associations between
                      autoimmune disease and HCC were observed for 13 autoimmune
                      diseases, with the highest risks being for autoimmune
                      hepatitis (48.92/73.53, men/women) and primary biliary
                      cirrhosis (38.03/54.48). GBC was increased after six
                      autoimmune diseases, with high SIRs for ulcerative colitis
                      (12.22/3.24) and men with Crohn disease (9.16). These
                      autoimmune diseases were also associated with a high risk of
                      iCCA, which had seven other associations, and eCCA, which
                      had five other associations. Ampullary cancer occurrence was
                      increased after four autoimmune diseases.An autoimmune
                      disease is a common precursor condition for hepatobiliary
                      cancers. This calls for careful control of autoimmune
                      disease symptoms in each patient and encouragement to
                      practice a healthy lifestyle.},
      keywords     = {comorbidity (Other) / discharge data (Other) /
                      hepatocellular cancer (Other) / immune disturbance (Other) /
                      risk factor (Other)},
      cin          = {C020 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36715017},
      doi          = {10.1002/cncr.34663},
      url          = {https://inrepo02.dkfz.de/record/212543},
}