%0 Journal Article
%A Tonn, Svenja
%A Korshunov, Andrey
%A Obrecht, Denise
%A Sill, Martin
%A Spohn, Michael
%A von Hoff, Katja
%A Milde, Till
%A Pietsch, Torsten
%A Goschzik, Tobias
%A Bison, Brigitte
%A Juhnke, Björn-Ole
%A Struve, Nina
%A Sturm, Dominik
%A Sahm, Felix
%A Bockmayr, Michael
%A Friedrich, Carsten
%A von Bueren, André O
%A Gerber, Nicolas U
%A Benesch, Martin
%A Jones, David
%A Kool, Marcel
%A Wefers, Annika K
%A Schüller, Ulrich
%A Pfister, Stefan
%A Rutkowski, Stefan
%A Mynarek, Martin
%T Risk prediction in early childhood SHH medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than two subgroups.
%J Neuro-Oncology
%V 25
%N 8
%@ 1522-8517
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2023-00229
%P 1518-1529
%D 2023
%Z 2023 Aug 3;25(8):1518-1529
%X The prognostic impact of clinical risk factors and DNA methylation patterns in sonic hedgehog (SHH)-activated early childhood desmoplastic/nodular medulloblastoma (DMB) or medulloblastoma with extensive nodularity (MBEN) were evaluated to better identify patients at risk for relapse.Hundred-forty-four patients with DMB (n=99) or MBEN (n=45) aged <5 years and treated with radiation-sparing approaches, including intraventricular methotrexate in 132 patients, were evaluated.Patients with DMB had less favorable 5-year progression-free survival than MBEN (5y-PFS, 71
%K DNA methylation profiling (Other)
%K Medulloblastoma (Other)
%K Risk prediction (Other)
%K Sonic hedgehog-activated (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36715306
%R 10.1093/neuonc/noad027
%U https://inrepo02.dkfz.de/record/212544