TY  - JOUR
AU  - Tonn, Svenja
AU  - Korshunov, Andrey
AU  - Obrecht, Denise
AU  - Sill, Martin
AU  - Spohn, Michael
AU  - von Hoff, Katja
AU  - Milde, Till
AU  - Pietsch, Torsten
AU  - Goschzik, Tobias
AU  - Bison, Brigitte
AU  - Juhnke, Björn-Ole
AU  - Struve, Nina
AU  - Sturm, Dominik
AU  - Sahm, Felix
AU  - Bockmayr, Michael
AU  - Friedrich, Carsten
AU  - von Bueren, André O
AU  - Gerber, Nicolas U
AU  - Benesch, Martin
AU  - Jones, David
AU  - Kool, Marcel
AU  - Wefers, Annika K
AU  - Schüller, Ulrich
AU  - Pfister, Stefan
AU  - Rutkowski, Stefan
AU  - Mynarek, Martin
TI  - Risk prediction in early childhood SHH medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than two subgroups.
JO  - Neuro-Oncology
VL  - 25
IS  - 8
SN  - 1522-8517
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2023-00229
SP  - 1518-1529
PY  - 2023
N1  - 2023 Aug 3;25(8):1518-1529
AB  - The prognostic impact of clinical risk factors and DNA methylation patterns in sonic hedgehog (SHH)-activated early childhood desmoplastic/nodular medulloblastoma (DMB) or medulloblastoma with extensive nodularity (MBEN) were evaluated to better identify patients at risk for relapse.Hundred-forty-four patients with DMB (n=99) or MBEN (n=45) aged <5 years and treated with radiation-sparing approaches, including intraventricular methotrexate in 132 patients, were evaluated.Patients with DMB had less favorable 5-year progression-free survival than MBEN (5y-PFS, 71
KW  - DNA methylation profiling (Other)
KW  - Medulloblastoma (Other)
KW  - Risk prediction (Other)
KW  - Sonic hedgehog-activated (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36715306
DO  - DOI:10.1093/neuonc/noad027
UR  - https://inrepo02.dkfz.de/record/212544
ER  -