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000212548 1001_ $$aKraus, Franziska V$$b0
000212548 245__ $$aReduction of pro-inflammatory effector functions through remodeling of fatty acid metabolism in CD8+ T-cells from rheumatoid arthritis patients.
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000212548 520__ $$aRheumatoid arthritis (RA) CD8+ T-cells (CD8) maintain their effector pro-inflammatory phenotype by changing their metabolism towards aerobic glycolysis. However, their massive energetic and biosynthetic needs may require additional substrates other than glucose. Since systemic alterations in lipid metabolism have been reported in RA patients, we explored the role of fatty acid (FA) metabolism in CD8 to identify potential targets to curb their pro-inflammatory potential.The expression of FA metabolism-related genes was analyzed for total and CD8-subsets in the data of RA patients and healthy controls retrieved from the gene expression omnibus database. Functional assays were performed on peripheral-blood CD8 isolated from RA (n=31), PsA (n=26), and SpA (n=21) patients under different therapies (DMARD, biologicals, and JAK inhibitors) and controls (n=13). We quantified the expression of FA transporters, lipid uptake, intracellular FA content, cytokine production, activation, proliferation, and capacity to inhibit tumor cell growth, either with or without FA metabolism inhibitors.The CD8 gene expression profile of FA metabolism-related genes was significantly different between untreated RA patients and controls. RA patients with a good clinical response after 6 months MTX therapy significantly increased the expression of FA metabolism-related genes. Cell-surface expression of FA transporters FABP4 and GPR84 and FA uptake was higher in effector and memory CD8 of RA patients than for controls. In vitro blockade of FA metabolism significantly impaired CD8 effector functions.RA CD8 present an altered FA metabolism which can provide potential therapeutic targets to control the pro-inflammatory profile. Particularly, therapies directed against the transport and oxidation of free FA.
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000212548 542__ $$2Crossref$$i2023-04-13$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
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000212548 7001_ $$aKeck, Simon$$b1
000212548 7001_ $$0P:(DE-He78)c53db83479d3d1265967405af71f69bb$$aKlika, Karel$$b2$$udkfz
000212548 7001_ $$aGraf, Jürgen$$b3
000212548 7001_ $$aCarvalho, Rui A$$b4
000212548 7001_ $$aLorenz, Hanns-Martin$$b5
000212548 7001_ $$00000-0001-6923-0590$$aSouto-Carneiro, M Margarida$$b6
000212548 77318 $$2Crossref$$3journal-article$$a10.1002/art.42456$$bWiley$$d2023-04-13$$tArthritis & Rheumatology$$x2326-5191$$y2023
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000212548 999C5 $$1Bole GG$$2Crossref$$9-- missing cx lookup --$$a10.1002/art.1780050606$$p589 -$$tArthritis Rheum$$v5$$y1962
000212548 999C5 $$1Ryu H$$2Crossref$$oRyu H 2019$$y2019
000212548 999C5 $$1Kidani Y$$2Crossref$$9-- missing cx lookup --$$a10.1038/ni.2570$$p489 -$$tNat Immunol$$v14$$y2013
000212548 999C5 $$1Souto‐Carneiro MM$$2Crossref$$9-- missing cx lookup --$$a10.1002/art.41420$$p2050 -$$tArthritis Rheumatol$$v72$$y2020
000212548 999C5 $$1Shen Y$$2Crossref$$9-- missing cx lookup --$$a10.1038/ni.3808$$p1025 -$$tNat Immunol$$v18$$y2017
000212548 999C5 $$1Bensinger SJ$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2008.04.052$$p97 -$$tCell$$v134$$y2008
000212548 999C5 $$1Qiu J$$2Crossref$$9-- missing cx lookup --$$a10.3389/fimmu.2021.652771$$tFront Immunol$$v12$$y2021
000212548 999C5 $$1Qian X$$2Crossref$$9-- missing cx lookup --$$a10.1111/sji.12713$$tScand J Immunol$$v88$$y2018
000212548 999C5 $$1Wang R$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.immuni.2011.09.021$$p871 -$$tImmunity$$v35$$y2011
000212548 999C5 $$1Pan Y$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature21379$$p252 -$$tNature$$v543$$y2017
000212548 999C5 $$1O'Sullivan D$$2Crossref$$oO'Sullivan D 2014$$y2014
000212548 999C5 $$1Zamora C$$2Crossref$$9-- missing cx lookup --$$a10.1189/jlb.0213074$$p521 -$$tJ Leukoc Biol$$v94$$y2013
000212548 999C5 $$1Xu S$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.immuni.2021.05.003$$p1561 -$$tImmunity$$v54$$y2021
000212548 999C5 $$1Wang J$$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M608019200$$p34457 -$$tJ Biol Chem$$v281$$y2006
000212548 999C5 $$1Benesova K$$2Crossref$$oBenesova K 2022$$y2022
000212548 999C5 $$1Gillespie M$$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gkab1028$$pD687 -$$tNucleic Acids Res$$v50$$y2022
000212548 999C5 $$1Isaacs JD$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41597-022-01264-y$$p196 -$$tSci Data$$v9$$y2022
000212548 999C5 $$1Inamo J$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41598-021-96300-z$$p16691 -$$tSci Rep$$v11$$y2021
000212548 999C5 $$1Takeshita M$$2Crossref$$oTakeshita M 2019$$y2019
000212548 999C5 $$1Yousif A$$2Crossref$$9-- missing cx lookup --$$a10.1186/s12859-020-03577-4$$p267 -$$tBMC Bioinformatics$$v21$$y2020
000212548 999C5 $$1Pang Z$$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gkab382$$pW388 -$$tNucleic Acids Res$$v49$$y2021
000212548 999C5 $$1Suzuki M$$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M112.420042$$p10684 -$$tJ Biol Chem$$v288$$y2013
000212548 999C5 $$1Ehehalt R$$2Crossref$$9-- missing cx lookup --$$a10.1186/1471-2121-9-45$$p45 -$$tBMC Cell Biol$$v9$$y2008
000212548 999C5 $$1Howie D$$2Crossref$$9-- missing cx lookup --$$a10.3389/fimmu.2017.01949$$p1949 -$$tFront Immunol$$v8$$y2017
000212548 999C5 $$1Pearce EL$$2Crossref$$9-- missing cx lookup --$$a10.1038/nature08097$$p103 -$$tNat$$v460$$y2009
000212548 999C5 $$1Allanore Y$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cca.2005.08.010$$p143 -$$tClin Chim Acta$$v365$$y2006
000212548 999C5 $$1Medcalf MR$$2Crossref$$9-- missing cx lookup --$$a10.3390/metabo11120824$$p824 -$$tMetabolites$$v11$$y2021
000212548 999C5 $$1Charles‐Schoeman C$$2Crossref$$9-- missing cx lookup --$$a10.1002/art.39502$$p577 -$$tArthritis Rheumatol$$v68$$y2016
000212548 999C5 $$1Kume K$$2Crossref$$9-- missing cx lookup --$$a10.1007/s00296-017-3844-9$$p2079 -$$tRheumatol Int$$v37$$y2017
000212548 999C5 $$1Navarro‐Millán I$$2Crossref$$9-- missing cx lookup --$$a10.1002/art.37916$$p1430 -$$tArthritis Rheum$$v65$$y2013
000212548 999C5 $$1Aarsaether N$$2Crossref$$9-- missing cx lookup --$$a10.1016/0005-2760(88)90247-0$$p70 -$$tBiochim Biophys Acta$$v958$$y1988
000212548 999C5 $$1Cronstein BN$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41584-020-0373-9$$p145 -$$tNat Rev Rheumatol$$v16$$y2020
000212548 999C5 $$1Xu L$$2Crossref$$9-- missing cx lookup --$$a10.1038/s41374-021-00679-2$$p25 -$$tLab Invest$$v102$$y2022
000212548 999C5 $$1Zhang Y$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ccell.2017.08.004$$p377 -$$tCancer Cell$$v32$$y2017
000212548 999C5 $$1Verlengia R$$2Crossref$$9-- missing cx lookup --$$a10.1016/j.lfs.2003.04.003$$p2939 -$$tLife Sci$$v73$$y2003
000212548 999C5 $$1Anderson EK$$2Crossref$$9-- missing cx lookup --$$a10.1161/ATVBAHA.112.250142$$p1687 -$$tArterioscler Thromb Vasc Biol$$v32$$y2012
000212548 999C5 $$1Miao H$$2Crossref$$9-- missing cx lookup --$$a10.1038/srep13092$$p13092 -$$tSci Rep$$v5$$y2015
000212548 999C5 $$1Finlay DK$$2Crossref$$9-- missing cx lookup --$$a10.1084/jem.20112607$$p2441 -$$tJ Exp Med$$v209$$y2012
000212548 999C5 $$1McCarey DW$$2Crossref$$9-- missing cx lookup --$$a10.1016/S0140-6736(04)16449-0$$p2015 -$$tLancet$$v363$$y2004