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@ARTICLE{Steidl:241141,
      author       = {E. Steidl$^*$ and K. Weber$^*$ and E. Hattingen$^*$ and J.
                      P. Steinbach$^*$ and G. D. Maurer},
      title        = {{L}ongitudinal study on {MRI} and neuropathological
                      findings: {N}either {DSC}-perfusion derived r{CBV}max nor
                      vessel densities correlate between newly diagnosed and
                      progressive glioblastoma.},
      journal      = {PLOS ONE},
      volume       = {18},
      number       = {2},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DKFZ-2023-00254},
      pages        = {e0274400 -},
      year         = {2023},
      abstract     = {When evaluating MRIs for glioblastoma progression, previous
                      scans are usually included into the review. Nowadays dynamic
                      susceptibility contrast (DSC)-perfusion is an essential
                      component in MR-diagnostics of gliomas, since the extent of
                      hyperperfusion upon first diagnosis correlates with gene
                      expression and survival. We aimed to investigate if this
                      initial perfusion signature also characterizes the
                      glioblastoma at time of progression. If so, DSC-perfusion
                      data from the initial diagnosis could be of diagnostic
                      benefit in follow-up assessments.We retrospectively
                      identified 65 patients with isocitrate dehydrogenase
                      wildtype glioblastoma who had received technically identical
                      DSC-perfusion measurements at initial diagnosis and at time
                      of first progression. We determined maximum relative
                      cerebral blood volume values (rCBVmax) by standardized
                      re-evaluation of the data including leakage correction. In
                      addition, the corresponding tissue samples from 24 patients
                      were examined histologically for the maximum vessel density
                      within the tumor. Differences (paired t-test/ Wilcoxon
                      matched pairs test) and correlations (Spearman) between the
                      measurements at both timepoints were calculated.The rCBVmax
                      was consistently lower at time of progression compared to
                      rCBVmax at time of first diagnosis (p < .001). There was no
                      correlation between the rCBVmax values at both timepoints (r
                      = .12). These findings were reflected in the histological
                      examination, with a lower vessel density in progressive
                      glioblastoma (p = .01) and no correlation between the two
                      timepoints (r = -.07).Our results suggest that the extent of
                      hyperperfusion in glioblastoma at first diagnosis is not a
                      sustaining tumor characteristic. Hence, the rCBVmax at
                      initial diagnosis should be disregarded when reviewing MRIs
                      for glioblastoma progression.},
      cin          = {FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)FM01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36724187},
      doi          = {10.1371/journal.pone.0274400},
      url          = {https://inrepo02.dkfz.de/record/241141},
}