%0 Journal Article
%A Klusa, Daria
%A Lohaus, Fabian
%A Franken, Andre
%A Baumbach, Marian
%A Cojoc, Monica
%A Dowling, Paul
%A Linge, Annett
%A Offermann, Anne
%A Löck, Steffen
%A Hušman, Dejan
%A Rivandi, Mahdi
%A Polzer, Bernhard
%A Freytag, Vera
%A Lange, Tobias
%A Neubauer, Hans
%A Kücken, Michael
%A Perner, Sven
%A Hölscher, Tobias
%A Dubrovska, Anna
%A Krause, Mechthild
%A Kurth, Ina
%A Baumann, Michael
%A Peitzsch, Claudia
%T Dynamics of CXCR4 positive circulating tumor cells in prostate cancer patients during radiotherapy.
%J International journal of cancer
%V 152
%N 12
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2023-00264
%P 2639-2654
%D 2023
%Z 2023 Jun 15;152(12):2639-2654
%X Ablative radiotherapy is a highly efficient treatment modality for patients with metastatic prostate cancer (PCa). However, a subset of patients does not respond. Currently, this subgroup with bad prognosis cannot be identified before disease progression. We hypothesize that markers indicative of radioresistance, stemness, and/or bone tropism may have a prognostic potential to identify patients profiting from the metastases-directed radiotherapy. Therefore, circulating tumor cells (CTCs) were analyzed in patients with metastatic PCa (n=24) during radiotherapy with CellSearch, multi-color flow cytometry and imaging cytometry. Analysis of copy-number alteration indicate a polyclonal CTC population that changes after radiotherapy. CTCs were found in 8 out of 24 patients (33.3 
%K CXCR4 (Other)
%K bone metastasis (Other)
%K circulating tumor cells (Other)
%K prostate cancer (Other)
%K radiotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36733230
%R 10.1002/ijc.34457
%U https://inrepo02.dkfz.de/record/241156