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@ARTICLE{Klusa:241156,
      author       = {D. Klusa and F. Lohaus$^*$ and A. Franken and M. Baumbach
                      and M. Cojoc and P. Dowling and A. Linge$^*$ and A.
                      Offermann and S. Löck and D. Hušman and M. Rivandi and B.
                      Polzer and V. Freytag and T. Lange and H. Neubauer and M.
                      Kücken and S. Perner and T. Hölscher$^*$ and A. Dubrovska
                      and M. Krause$^*$ and I. Kurth$^*$ and M. Baumann$^*$ and C.
                      Peitzsch},
      title        = {{D}ynamics of {CXCR}4 positive circulating tumor cells in
                      prostate cancer patients during radiotherapy.},
      journal      = {International journal of cancer},
      volume       = {152},
      number       = {12},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2023-00264},
      pages        = {2639-2654},
      year         = {2023},
      note         = {2023 Jun 15;152(12):2639-2654},
      abstract     = {Ablative radiotherapy is a highly efficient treatment
                      modality for patients with metastatic prostate cancer (PCa).
                      However, a subset of patients does not respond. Currently,
                      this subgroup with bad prognosis cannot be identified before
                      disease progression. We hypothesize that markers indicative
                      of radioresistance, stemness, and/or bone tropism may have a
                      prognostic potential to identify patients profiting from the
                      metastases-directed radiotherapy. Therefore, circulating
                      tumor cells (CTCs) were analyzed in patients with metastatic
                      PCa (n=24) during radiotherapy with CellSearch, multi-color
                      flow cytometry and imaging cytometry. Analysis of
                      copy-number alteration indicate a polyclonal CTC population
                      that changes after radiotherapy. CTCs were found in 8 out of
                      24 patients (33.3 $\%)$ and were associated with a shorter
                      time to biochemical progression after radiotherapy. Whereas
                      the total CTC count dropped after radiotherapy, a chemokine
                      receptor CXCR4-expressing subpopulation representing 28.6
                      $\%$ of the total CTC population remained stable up to three
                      months. At once, we observed higher chemokine CCL2 plasma
                      concentrations and pro-inflammatory monocytes. Additional
                      functional analyses demonstrated key roles of CXCR4 and CCL2
                      for cellular radiosensitivity, tumorigenicity and stem-like
                      potential in vitro and in vivo. Moreover, a high CXCR4 and
                      CCL2 expression was found in bone metastasis biopsies of PCa
                      patients. In summary, panCK+ CXCR4+ CTCs may have a
                      prognostic potential in patients with metastatic PCa treated
                      with metastasis-directed radiotherapy. This article is
                      protected by copyright. All rights reserved.},
      keywords     = {CXCR4 (Other) / bone metastasis (Other) / circulating tumor
                      cells (Other) / prostate cancer (Other) / radiotherapy
                      (Other)},
      cin          = {DD01 / E220},
      ddc          = {610},
      cid          = {I:(DE-He78)DD01-20160331 / I:(DE-He78)E220-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36733230},
      doi          = {10.1002/ijc.34457},
      url          = {https://inrepo02.dkfz.de/record/241156},
}