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@ARTICLE{Preisner:241161,
      author       = {F. Preisner and J. C. Hayes and T. Charlet and F. Carinci
                      and T. Hielscher$^*$ and D. Schwarz and D. F. Vollherbst and
                      M. O. Breckwoldt and J. Jesser and S. Heiland and M.
                      Bendszus and T. Hilgenfeld},
      title        = {{S}imultaneous {M}ultislice {A}ccelerated {TSE} for
                      {I}mproved {S}patiotemporal {R}esolution and {D}iagnostic
                      {A}ccuracy in {M}agnetic {R}esonance {N}eurography: {A}
                      {F}easibility {S}tudy.},
      journal      = {Investigative radiology},
      volume       = {58},
      number       = {5},
      issn         = {0020-9996},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2023-00269},
      pages        = {363-371},
      year         = {2023},
      note         = {2023 May 1;58(5):363-371},
      abstract     = {This study aims to evaluate the utility of simultaneous
                      multislice (SMS) acceleration for routine magnetic resonance
                      neurography (MRN) at 3 T.Patients with multiple sclerosis
                      underwent MRN of the sciatic nerve consisting of a standard
                      fat-saturated T2-weighted turbo spin echo (TSE) sequence
                      using integrated parallel acquisition technique (PAT2)
                      acceleration and 2 T2 TSE sequences using a combination of
                      PAT-SMS acceleration (1) to reduce scan time (PAT2-SMS2;
                      SMS-TSEFAST) and (2) for time neutral increase of in-plane
                      resolution (PAT1-SMS2; SMS-TSEHR). Acquisition times were
                      5:29 minutes for the standard T2 TSE, 3:12 minutes for the
                      SMS-TSEFAST, and 5:24 minutes for the SMS-TSEHR. Six
                      qualitative imaging parameters were analyzed by 2 blinded
                      readers using a 5-point Likert scale and T2 nerve lesions
                      were quantified, respectively. Qualitative and quantitative
                      image parameters were compared, and both interrater and
                      intrarater reproducibility were statistically assessed. In
                      addition, signal-to-noise ratio/contrast-to-noise ratio
                      (CNR) was obtained in healthy controls using the exact same
                      imaging protocol.A total of 15 patients with MS (mean age ±
                      standard deviation, 38.1 ± 11 years) and 10 healthy
                      controls (mean age, 29.1 ± 7 years) were enrolled in this
                      study. CNR analysis was highly reliable (intraclass
                      correlation coefficient, 0.755-0.948) and revealed a
                      significant CNR decrease for the sciatic nerve for both SMS
                      protocols compared with standard T2 TSE
                      (SMS-TSEFAST/SMS-TSEHR, $-39\%/-55\%;$ P ≤ 0.01).
                      Intrarater and interrater reliability of qualitative image
                      review was good to excellent (κ: 0.672-0.971/0.617-0.883).
                      Compared with the standard T2 TSE sequence, both SMS methods
                      were shown to be superior in reducing pulsatile flow
                      artifacts (P < 0.01). Ratings for muscle border sharpness,
                      detailed muscle structures, nerve border sharpness, and
                      nerve fascicular structure did not differ significantly
                      between the standard T2 TSE and the SMS-TSEFAST (P > 0.05)
                      and were significantly better for the SMS-TSEHR than for
                      standard T2 TSE (P < 0.001). Muscle signal homogeneity was
                      mildly inferior for both SMS-TSEFAST (P > 0.05) and
                      SMS-TSEHR (P < 0.001). A significantly higher number of T2
                      nerve lesions were detected by SMS-TSEHR (P ≤ 0.01)
                      compared with the standard T2 TSE and SMS-TSEFAST, whereas
                      no significant difference was observed between the standard
                      T2 TSE and SMS-TSEFAST.Implementation of SMS offers either
                      to substantially reduce acquisition time by over $40\%$
                      without significantly impeding image quality compared with
                      the standard T2 TSE or to increase in-plane resolution for a
                      high-resolution approach and improved depiction of T2 nerve
                      lesions while keeping acquisition times constant. This
                      addresses the specific needs of MRN by providing different
                      imaging approaches for 2D clinical MRN.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36729753},
      doi          = {10.1097/RLI.0000000000000940},
      url          = {https://inrepo02.dkfz.de/record/241161},
}