TY  - JOUR
AU  - Mukama, Trasias
AU  - Johnson, Theron
AU  - Kaaks, Rudolf
AU  - Katzke, Verena
TI  - A case-cohort study of the association between adiponectin and mortality in EPIC-Heidelberg: NT-proBNP may explain the adiponectin paradox.
JO  - Nutrition, metabolism and cardiovascular diseases
VL  - 33
IS  - 4
SN  - 0939-4753
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-00284
SP  - 853-863
PY  - 2023
N1  - #EA:C020#LA:C020# / 2023 Apr;33(4):853-863
AB  - NT-proBNP has been hypothesized as a possible explanation for the paradoxical association between adiponectin and cardiovascular and all-cause mortality. We examined the heterogeneities by NT-proBNP, sex, BMI, smoking status, hypertension and diabetes status in the association between adiponectin and cardiovascular disease risk and mortality.We used a case-cohort design nested within the EPIC-Heidelberg cohort, including 1387 incident cases of myocardial infarction or stroke, 582 deaths from cardiovascular causes and 2352 total deaths. We estimated hazard ratios for the association between 1SD increase in log-transformed total adiponectin levels and cardiovascular disease risk, cardiovascular mortality and mortality using Prentice-weighted Cox-proportional hazard models and assessed heterogeneity of the associations across strata of covariates. Overall, adiponectin was significantly associated with all-cause mortality [HR = 1.09, 95
KW  - Adiponectin paradox (Other)
KW  - All-cause mortality (Other)
KW  - Cardiovascular disease risk (Other)
KW  - Cardiovascular mortality (Other)
KW  - NT-proBNP (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36740561
DO  - DOI:10.1016/j.numecd.2023.01.014
UR  - https://inrepo02.dkfz.de/record/265122
ER  -