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@ARTICLE{Mukama:265122,
      author       = {T. Mukama$^*$ and T. Johnson$^*$ and R. Kaaks$^*$ and V.
                      Katzke$^*$},
      title        = {{A} case-cohort study of the association between
                      adiponectin and mortality in {EPIC}-{H}eidelberg:
                      {NT}-pro{BNP} may explain the adiponectin paradox.},
      journal      = {Nutrition, metabolism and cardiovascular diseases},
      volume       = {33},
      number       = {4},
      issn         = {0939-4753},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-00284},
      pages        = {853-863},
      year         = {2023},
      note         = {#EA:C020#LA:C020# / 2023 Apr;33(4):853-863},
      abstract     = {NT-proBNP has been hypothesized as a possible explanation
                      for the paradoxical association between adiponectin and
                      cardiovascular and all-cause mortality. We examined the
                      heterogeneities by NT-proBNP, sex, BMI, smoking status,
                      hypertension and diabetes status in the association between
                      adiponectin and cardiovascular disease risk and mortality.We
                      used a case-cohort design nested within the EPIC-Heidelberg
                      cohort, including 1387 incident cases of myocardial
                      infarction or stroke, 582 deaths from cardiovascular causes
                      and 2352 total deaths. We estimated hazard ratios for the
                      association between 1SD increase in log-transformed total
                      adiponectin levels and cardiovascular disease risk,
                      cardiovascular mortality and mortality using
                      Prentice-weighted Cox-proportional hazard models and
                      assessed heterogeneity of the associations across strata of
                      covariates. Overall, adiponectin was significantly
                      associated with all-cause mortality [HR = 1.09, $95\%$ CI:
                      1.03-1.16, p = 0.004]. The association with cardiovascular
                      mortality did not reach statistical significance [1.10
                      (0.99-1.37), p = 0.073]. There was significant heterogeneity
                      by NT-proBNP in the association between total adiponectin
                      and all-cause mortality (phet = 0.019) such that significant
                      increase in hazards of mortality were restricted to
                      participants in the highest tertile of NT-proBNP. Among
                      these participants, adiponectin showed a dose-response
                      relationship with total mortality such that; compared to
                      participants in the lowest quintile, those in the third,
                      fourth and fifth were at 1.22 (0.87-1.70), 1.50 (1.07-2.11),
                      and 1.59 (1.15-2.21) higher hazards of mortality
                      respectively.Significant association between adiponectin and
                      mortality was only observed in the context of high
                      NT-proBNP. Our findings provide further support for
                      hypothesis that NT-proBNP may explain the adiponectin
                      paradox.},
      keywords     = {Adiponectin paradox (Other) / All-cause mortality (Other) /
                      Cardiovascular disease risk (Other) / Cardiovascular
                      mortality (Other) / NT-proBNP (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36740561},
      doi          = {10.1016/j.numecd.2023.01.014},
      url          = {https://inrepo02.dkfz.de/record/265122},
}