TY  - JOUR
AU  - Sparber-Sauer, Monika
AU  - Ferrari, Andrea
AU  - Spunt, Sheri L
AU  - Vokuhl, Christian
AU  - Casey, Dana
AU  - Lautz, Timothy B
AU  - Meyer, William H
AU  - Walterhouse, David O
AU  - Pajtler, Kristian W
AU  - Alaggio, Rita
AU  - Schmidt, Andreas
AU  - Safwat, Akmal
AU  - Timmermann, Beate
AU  - Dall'Igna, Patrizia
AU  - Chen, Sonja
AU  - Weiss, Aaron R
AU  - Orbach, Daniel
TI  - The significance of margins in pediatric Non-Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT).
JO  - Cancer medicine
VL  - 12
IS  - 10
SN  - 2045-7634
CY  - Hoboken, NJ
PB  - Wiley
M1  - DKFZ-2023-00292
SP  - 11719-11730
PY  - 2023
N1  - 2023 May;12(10):11719-11730
AB  - Margin status following surgery in children, adolescents, and young adults with soft tissue sarcomas is controversial and has been defined differently by various specialties, with definitions changing over time and by cooperative group. The International Soft Tissue Sarcoma Consortium (INSTRuCT) is a collaboration of the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee, European pediatric Soft Tissue sarcoma Study Group (EpSSG), and the European Cooperative Weichteilsarkom Studiengruppe (CWS) devoted to improving patient outcomes by pooling and mining cooperative group clinical trial data.The INSTRuCT non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) working group aimed to develop international harmonized recommendations regarding surgical margin assessment and definitions in children and adolescents with soft tissue tumors.This review addresses accepted principles and areas of controversy, including the perspectives of surgeons, pathologists, radiation oncologists, and pediatric oncologists, to develop a framework for building common guidelines for future research.
KW  - margins (Other)
KW  - pediatric/adolescent oncology (Other)
KW  - radiotherapy (Other)
KW  - soft tissue sarcoma (Other)
KW  - surgery (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36744538
DO  - DOI:10.1002/cam4.5671
UR  - https://inrepo02.dkfz.de/record/265697
ER  -