% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{TurzanskiFortner:265702,
      author       = {R. Turzanski-Fortner$^*$ and K. D. Brantley and S. S.
                      Tworoger and R. M. Tamimi and B. Rosner and M. S. Farvid and
                      M. D. Holmes and W. C. Willett and A. H. Eliassen},
      title        = {{P}hysical activity and breast cancer survival: results
                      from the {N}urses' {H}ealth {S}tudies.},
      journal      = {JNCI cancer spectrum},
      volume       = {7},
      number       = {1},
      issn         = {2515-5091},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2023-00297},
      pages        = {pkac085},
      year         = {2023},
      note         = {#EA:C020#},
      abstract     = {Physical activity is generally associated with better
                      outcomes following diagnosis; however, few studies have
                      evaluated change in pre- to postdiagnosis activity and
                      repeated measures of activity by intensity and type.We
                      evaluated physical activity and survival following a breast
                      cancer diagnosis in the Nurses' Health Study and Nurses'
                      Health Study II (n = 9308 women, n = 1973 deaths). Physical
                      activity was evaluated as updated cumulative average of
                      metabolic equivalent of task (MET)-h/wk (assigned per
                      activity based on duration and intensity) and change in pre-
                      to postdiagnosis activity. Cox proportional hazards models
                      were used to estimate hazard ratios (HRs) and $95\%$
                      confidence intervals (CIs).Higher postdiagnosis activity was
                      inversely associated with breast cancer-specific mortality
                      in categories from ≥9 MET-h/wk (vs <3 MET h/wk, HR≥9 to
                      <18 = 0.74 $[95\%$ CI = 0.55 to 0.99]; HR≥27 = 0.69
                      $[95\%$ CI = 0.50 to 0.95]; Ptrend = .04) and all-cause
                      mortality from ≥3 MET-h/wk (HR≥3 to <9 = 0.73 $[95\%$ CI
                      = 0.61 to 0.88]; HR≥27 = 0.51 $[95\%$ CI = 0.41 to 0.63];
                      Ptrend < .001). Associations were predominantly observed for
                      estrogen receptor-positive tumors and in postmenopausal
                      women. Walking was associated with lower risk of all-cause
                      mortality (≥9 vs <3 MET-h/wk, HR= 0.69 $[95\%$ CI = 0.57
                      to 0.84]) as was strength training. Relative to stable
                      activity pre- to postdiagnosis (±3 MET-h/wk), increases
                      from ≥3 to 9 MET-h/wk were associated with lower all-cause
                      mortality risk (Ptrend < .001). Results were robust to
                      adjustment for prediagnosis physical activity.Physical
                      activity was associated with lower risk of death following
                      diagnosis. Increased pre- to postdiagnosis activity
                      corresponding to at least 1-3 h/wk of walking was associated
                      with lower risk of death. These results provide further
                      impetus for women to increase their activity after a breast
                      cancer diagnosis, though reverse causation cannot be fully
                      excluded.},
      keywords     = {Humans / Female / Breast Neoplasms: diagnosis / Exercise /
                      Proportional Hazards Models / Prospective Studies / Nurses},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36477805},
      pmc          = {pmc:PMC9893869},
      doi          = {10.1093/jncics/pkac085},
      url          = {https://inrepo02.dkfz.de/record/265702},
}