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@ARTICLE{Rhle:267537,
      author       = {A. Rühle$^*$ and J. Zou$^*$ and M. Glaser and L. Halle and
                      E. Gkika$^*$ and H. Schäfer$^*$ and A. Knopf and C. Becker
                      and A.-L. Grosu$^*$ and I. Popp$^*$ and N. Nicolay$^*$},
      title        = {{T}he influence of antibiotic administration on the
                      outcomes of head-and-neck squamous cell carcinoma patients
                      undergoing definitive (chemo)radiation.},
      journal      = {European archives of oto-rhino-laryngology and head $\&$
                      neck},
      volume       = {280},
      number       = {5},
      issn         = {0365-5245},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-00315},
      pages        = {2605-2616},
      year         = {2023},
      note         = {#LA:E055# / 2023 May;280(5):2605-2616},
      abstract     = {Effects of antibiotic administration on patients'
                      microbiome may negatively influence cancer outcomes, and
                      adverse prognoses after antibiotic application have been
                      demonstrated for cancer patients receiving immune checkpoint
                      inhibitors. While the microbiome may play an important role
                      also in head-and-neck squamous cell carcinoma (HNSCC), the
                      prognostic value of antibiotic treatment here is largely
                      unknown. We therefore analyzed whether antibiotic
                      prescription is associated with impaired oncological
                      outcomes of HNSCC patients undergoing definitive
                      (chemo)radiation.A cohort of 220 HNSCC patients undergoing
                      definitive (chemo)radiation between 2010 and 2019 was
                      analyzed. The influence of antibiotic administration on
                      locoregional control, progression-free survival (PFS) and
                      overall survival (OS) was determined using Kaplan-Meier and
                      Cox analyses.A total of 154 patients were treated with
                      antibiotics within 30 days before (chemo)radiation
                      (pretherapeutic) or during (chemo)radiation
                      (peritherapeutic). While antibiotic prescription was not
                      associated with age, ECOG, tumor localization or
                      radiotherapy characteristics, patients treated with
                      antibiotics had significantly higher tumor stages.
                      Peritherapeutic antibiotic administration diminished PFS (HR
                      = 1.397, p < 0.05, log-rank test) and OS (HR = 1.407, p <
                      0.05), whereas pretherapeutic administration did not.
                      Antibiotic application was an independent prognosticator for
                      OS (HR = 1.703, p < 0.05) and PFS (HR = 1.550, p < 0.05) in
                      the multivariate Cox analysis within the subgroup of
                      patients aged < 75 years.Peritherapeutic antibiotic usage
                      was associated with impaired oncological outcomes in HNSCC
                      patients undergoing (chemo)radiation. Further studies
                      including microbiome analyses are required to elucidate
                      underlying mechanisms.},
      keywords     = {Antibiotics (Other) / Chemoradiation (Other) /
                      Head-and-neck cancer (Other) / Head-and-neck squamous cell
                      carcinoma (Other) / Radiotherapy (Other)},
      cin          = {E055 / FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)E055-20160331 / I:(DE-He78)FR01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36764957},
      doi          = {10.1007/s00405-023-07868-3},
      url          = {https://inrepo02.dkfz.de/record/267537},
}