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@ARTICLE{SandovalBojrquez:267540,
      author       = {D. I. Sandoval Bojórquez and Ž. Janićijević and B.
                      Palestina Romero and E. S. Oliveros Mata and M. Laube and A.
                      Feldmann and A. Kegler and L. Drewitz and C. Fowley and J.
                      Pietzsch and J. Fassbender and T. Tonn and M. Bachmann$^*$
                      and L. Baraban},
      title        = {{I}mpedimetric {N}anobiosensor for the {D}etection of
                      {SARS}-{C}o{V}-2 {A}ntigens and {A}ntibodies.},
      journal      = {ACS sensors},
      volume       = {8},
      number       = {2},
      issn         = {2379-3694},
      address      = {Washington, DC},
      publisher    = {ACS Publications},
      reportid     = {DKFZ-2023-00318},
      pages        = {576-586},
      year         = {2023},
      note         = {2023 Feb 10;8(2):576-586},
      abstract     = {Detection of antigens and antibodies (Abs) is of great
                      importance in determining the infection and immunity status
                      of the population, as they are key parameters guiding the
                      handling of pandemics. Current point-of-care (POC) devices
                      are a convenient option for rapid screening; however, their
                      sensitivity requires further improvement. We present an
                      interdigitated gold nanowire-based impedance nanobiosensor
                      to detect COVID-19-associated antigens (receptor-binding
                      domain of S1 protein of the SARS-CoV-2 virus) and respective
                      Abs appearing during and after infection. The
                      electrochemical impedance spectroscopy technique was used to
                      assess the changes in measured impedance resulting from the
                      binding of respective analytes to the surface of the chip.
                      After 20 min of incubation, the sensor devices demonstrate a
                      high sensitivity of about 57 pS·sn per concentration decade
                      and a limit of detection (LOD) of 0.99 pg/mL for
                      anti-SARS-CoV-2 Abs and a sensitivity of around 21 pS·sn
                      per concentration decade and an LOD of 0.14 pg/mL for the
                      virus antigen detection. Finally, the analysis of clinical
                      plasma samples demonstrates the applicability of the
                      developed platform to assist clinicians and authorities in
                      determining the infection or immunity status of the
                      patients.},
      keywords     = {SARS-CoV-2 (Other) / electrochemical impedance spectroscopy
                      (EIS) (Other) / gold nanowires (Other) / impedance model
                      (Other) / impedimetric sensing (Other) / point-of-care
                      testing (Other) / reliability (Other) / surface plasmon
                      resonance (SPR) (Other)},
      cin          = {DD01},
      ddc          = {570},
      cid          = {I:(DE-He78)DD01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36763494},
      doi          = {10.1021/acssensors.2c01686},
      url          = {https://inrepo02.dkfz.de/record/267540},
}