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000271004 1001_ $$aDeniz, Ilker A$$b0
000271004 245__ $$aMesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin.
000271004 260__ $$aLondon$$bBiomed Central$$c2023
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000271004 520__ $$aMultipotent mesenchymal stromal cells (MSCs) are precursors of various cell types. Through soluble factors, direct cell-cell interactions and other intercellular communication mechanisms such as extracellular vesicles and tunneling nanotubes, MSCs support tissue homeostasis. In the bone marrow microenvironment, they promote hematopoiesis. The interaction between MSCs and cancer cells enhances the cancer and metastatic potential. Here, we have demonstrated that plastic-adherent MSCs isolated from human bone marrow generate migrasomes, a newly discovered organelle playing a role in intercellular communication.Migrasomes are forming a network with retraction fibers behind the migrating MSCs or surrounding them after membrane retraction. The MSC markers, CD44, CD73, CD90, CD105 and CD166 are present on the migrasome network, the latter being specific to migrasomes. Some migrasomes harbor the late endosomal GTPase Rab7 and exosomal marker CD63 indicating the presence of multivesicular bodies. Stromal cell-derived factor 1 (SDF-1) was detected in migrasomes, suggesting that they play a chemoattractant role. Co-cultures with KG-1a leukemic cells or primary CD34+ hematopoietic progenitors revealed that MSC-associated migrasomes attracted them, a process intercepted by the addition of AMD3100, a specific CXCR4 receptor inhibitor, or recombinant SDF-1. An antibody directed against CD166 reduced the association of hematopoietic cells and MSC-associated migrasomes. In contrast to primary CD34+ progenitors, leukemic cells can take up migrasomes.Overall, we described a novel mechanism used by MSCs to communicate with cells of hematopoietic origin and further studies are needed to decipher all biological aspects of migrasomes in the healthy and transformed bone marrow microenvironment. Video Abstract.
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000271004 650_7 $$2Other$$aCellular adhesion
000271004 650_7 $$2Other$$aExtracellular vesicle
000271004 650_7 $$2Other$$aHematopoietic stem cell
000271004 650_7 $$2Other$$aIntercellular signaling
000271004 650_7 $$2Other$$aMesenchymal stromal cell
000271004 650_7 $$2Other$$aMigrasome
000271004 650_7 $$2Other$$aMotility
000271004 650_7 $$2NLM Chemicals$$aChemotactic Factors
000271004 650_7 $$2NLM Chemicals$$aTunneling Nanotubes
000271004 650_7 $$2NLM Chemicals$$aAntigens, CD34
000271004 650_2 $$2MeSH$$aHumans
000271004 650_2 $$2MeSH$$aChemotactic Factors: metabolism
000271004 650_2 $$2MeSH$$aMesenchymal Stem Cells: metabolism
000271004 650_2 $$2MeSH$$aHematopoietic Stem Cells
000271004 650_2 $$2MeSH$$aCells, Cultured
000271004 650_2 $$2MeSH$$aAntigens, CD34: metabolism
000271004 650_2 $$2MeSH$$aBone Marrow Cells
000271004 650_2 $$2MeSH$$aCell Differentiation
000271004 650_2 $$2MeSH$$aStromal Cells: metabolism
000271004 7001_ $$aKarbanová, Jana$$b1
000271004 7001_ $$aWobus, Manja$$b2
000271004 7001_ $$aBornhäuser, Martin$$b3
000271004 7001_ $$0P:(DE-HGF)0$$aWimberger, Pauline$$b4
000271004 7001_ $$0P:(DE-HGF)0$$aKuhlmann, Jan Dominik$$b5
000271004 7001_ $$aCorbeil, Denis$$b6
000271004 773__ $$0PERI:(DE-600)2126315-2$$a10.1186/s12964-022-01028-6$$gVol. 21, no. 1, p. 36$$n1$$p36$$tCell communication and signaling$$v21$$x1478-811X$$y2023
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