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000271228 1001_ $$aYammine, S. G.$$b0
000271228 245__ $$aDietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.
000271228 260__ $$aHeidelberg$$bSpringer$$c2023
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000271228 520__ $$aDiet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons.Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk.Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.
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000271228 650_7 $$2Other$$aDiet
000271228 650_7 $$2Other$$aEndometrial cancer
000271228 650_7 $$2Other$$aEpidemiology
000271228 650_7 $$2Other$$aFatty acids
000271228 7001_ $$aHuybrechts, I.$$b1
000271228 7001_ $$aBiessy, C.$$b2
000271228 7001_ $$aDossus, L.$$b3
000271228 7001_ $$aPanico, S.$$b4
000271228 7001_ $$aSánchez, M. J.$$b5
000271228 7001_ $$aBenetou, V.$$b6
000271228 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aTurzanski-Fortner, R.$$b7$$udkfz
000271228 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, V.$$b8$$udkfz
000271228 7001_ $$aIdahl, A.$$b9
000271228 7001_ $$aSkeie, G.$$b10
000271228 7001_ $$aOlsen, K Standahl$$b11
000271228 7001_ $$aTjønneland, A.$$b12
000271228 7001_ $$aHalkjaer, J.$$b13
000271228 7001_ $$aColorado-Yohar, S.$$b14
000271228 7001_ $$aHeath, A. K.$$b15
000271228 7001_ $$aSonestedt, E.$$b16
000271228 7001_ $$aSartor, H.$$b17
000271228 7001_ $$aSchulze, M. B.$$b18
000271228 7001_ $$aPalli, D.$$b19
000271228 7001_ $$aCrous-Bou, M.$$b20
000271228 7001_ $$aDorronsoro, A.$$b21
000271228 7001_ $$aOvervad, K.$$b22
000271228 7001_ $$aGurrea, A Barricarte$$b23
000271228 7001_ $$aSeveri, G.$$b24
000271228 7001_ $$aVermeulen, R. C. H.$$b25
000271228 7001_ $$aSandanger, T. M.$$b26
000271228 7001_ $$aTravis, R. C.$$b27
000271228 7001_ $$aKey, T.$$b28
000271228 7001_ $$aAmiano, P.$$b29
000271228 7001_ $$aVan Guelpen, B.$$b30
000271228 7001_ $$aJohansson, M.$$b31
000271228 7001_ $$aSund, M.$$b32
000271228 7001_ $$aTumino, R.$$b33
000271228 7001_ $$aWareham, N.$$b34
000271228 7001_ $$aSacerdote, C.$$b35
000271228 7001_ $$aKrogh, V.$$b36
000271228 7001_ $$aBrennan, P.$$b37
000271228 7001_ $$aRiboli, E.$$b38
000271228 7001_ $$aWeiderpass, E.$$b39
000271228 7001_ $$aGunter, M. J.$$b40
000271228 7001_ $$aChajès, V.$$b41
000271228 773__ $$0PERI:(DE-600)2041352-X$$a10.1186/s12885-023-10611-0$$gVol. 23, no. 1, p. 159$$n1$$p159$$tBMC cancer$$v23$$x1471-2407$$y2023
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