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@ARTICLE{Yammine:271228,
      author       = {S. G. Yammine and I. Huybrechts and C. Biessy and L. Dossus
                      and S. Panico and M. J. Sánchez and V. Benetou and R.
                      Turzanski-Fortner$^*$ and V. Katzke$^*$ and A. Idahl and G.
                      Skeie and K. S. Olsen and A. Tjønneland and J. Halkjaer and
                      S. Colorado-Yohar and A. K. Heath and E. Sonestedt and H.
                      Sartor and M. B. Schulze and D. Palli and M. Crous-Bou and
                      A. Dorronsoro and K. Overvad and A. B. Gurrea and G. Severi
                      and R. C. H. Vermeulen and T. M. Sandanger and R. C. Travis
                      and T. Key and P. Amiano and B. Van Guelpen and M. Johansson
                      and M. Sund and R. Tumino and N. Wareham and C. Sacerdote
                      and V. Krogh and P. Brennan and E. Riboli and E. Weiderpass
                      and M. J. Gunter and V. Chajès},
      title        = {{D}ietary fatty acids and endometrial cancer risk within
                      the {E}uropean {P}rospective {I}nvestigation into {C}ancer
                      and {N}utrition.},
      journal      = {BMC cancer},
      volume       = {23},
      number       = {1},
      issn         = {1471-2407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-00365},
      pages        = {159},
      year         = {2023},
      abstract     = {Diet may impact important risk factors for endometrial
                      cancer such as obesity and inflammation. However, evidence
                      on the role of specific dietary factors is limited. We
                      investigated associations between dietary fatty acids and
                      endometrial cancer risk in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC).This analysis
                      includes 1,886 incident endometrial cancer cases and 297,432
                      non-cases. All participants were followed up for a mean of
                      8.8 years. Multivariable Cox proportional hazard models were
                      used to estimate hazard ratios (HR) and $95\%$ confidence
                      intervals (CI) of endometrial cancer across quintiles of
                      individual fatty acids estimated from various food sources
                      quantified through food frequency questionnaires in the
                      entire EPIC cohort. The false discovery rate (q-values) was
                      computed to control for multiple comparisons.Consumption of
                      n-6 γ-linolenic acid was inversely associated with
                      endometrial cancer risk (HR comparing 5th with 1st
                      quintileQ5-Q1=0.77, $95\%$ CI = 0.64; 0.92, ptrend=0.01,
                      q-value = 0.15). This association was mainly driven by
                      γ-linolenic acid derived from plant sources (HRper unit
                      increment=0.94, $95\%CI=$ (0.90;0.98), p = 0.01) but not
                      from animal sources (HRper unit increment= 1.00, $95\%CI$ =
                      (0.92; 1.07), p = 0.92). In addition, an inverse association
                      was found between consumption of n-3 α-linolenic acid from
                      vegetable sources and endometrial cancer risk (HRper unit
                      increment= 0.93, $95\%CI$ = (0.87; 0.99), p = 0.04). No
                      significant association was found between any other fatty
                      acids (individual or grouped) and endometrial cancer
                      risk.Our results suggest that higher consumption of
                      γ-linolenic acid and α-linoleic acid from plant sources
                      may be associated with lower risk of endometrial cancer.},
      keywords     = {Diet (Other) / Endometrial cancer (Other) / Epidemiology
                      (Other) / Fatty acids (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36797668},
      pmc          = {pmc:PMC9936701},
      doi          = {10.1186/s12885-023-10611-0},
      url          = {https://inrepo02.dkfz.de/record/271228},
}