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@ARTICLE{Gaito:271244,
      author       = {S. Gaito and E. J. Hwang and A. France and M. C. Aznar and
                      N. Burnet and A. Crellin and A. L. Holtzman and D. J.
                      Indelicato and B. Timmerman$^*$ and G. A. Whitfield and E.
                      Smith},
      title        = {{O}utcomes of {P}atients {T}reated in the {UK} {P}roton
                      {O}verseas {P}rogramme: {C}entral {N}ervous {S}ystem
                      {G}roup.},
      journal      = {Clinical oncology},
      volume       = {35},
      number       = {5},
      issn         = {0936-6555},
      address      = {[Erscheinungsort nicht ermittelbar]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2023-00376},
      pages        = {283-291},
      year         = {2023},
      note         = {2023 May;35(5):283-291},
      abstract     = {In 2008, the UK National Health Service started the Proton
                      Overseas Programme (POP), to provide access for proton beam
                      therapy (PBT) abroad for selected tumour diagnoses while two
                      national centres were being planned. The clinical outcomes
                      for the patient group treated for central nervous system
                      (CNS), base of skull, spinal and paraspinal malignancies are
                      reported here.Since the start of the POP, an agreement
                      between the National Health Service and UK referring centres
                      ensured outcomes data collection, including overall
                      survival, local tumour control and late toxicity data.
                      Clinical and treatment-related data were extracted from this
                      national patient database. Grade ≥3 late toxicities were
                      reported following Common Terminology Criteria for Adverse
                      Events (CTCAE) v 4.0 definition, occurring later than 90
                      days since the completion of treatment.Between 2008 and
                      September 2020, 830 patients were treated within the POP for
                      the above listed malignancies. Overall survival data were
                      available for 815 patients and local control data for 726
                      patients. Toxicity analysis was carried out on 702 patients,
                      with patients excluded due to short follow-up (<90 days)
                      and/or inadequate toxicity data available. After a median
                      follow-up of 3.34 years (0.06-11.58), the overall survival
                      was $91.2\%.$ The local control rate was $85.9\%$ after a
                      median follow-up of 2.81 years (range 0.04-11.58). The
                      overall grade ≥3 late toxicity incidence was $11.97\%,$
                      after a median follow-up of 1.72 years (0.04-8.45). The
                      median radiotherapy prescription dose was 54 GyRBE
                      (34.8-79.2).The results of this study indicate the safety of
                      PBT for CNS tumours. Preliminary clinical outcomes following
                      PBT for paediatric/teen and young adult and adult CNS
                      tumours treated within the POP are encouraging, which
                      reflects accurate patient selection and treatment quality.
                      The rate of late effects compares favourably with published
                      cohorts. Clinical outcomes from this patient cohort will be
                      compared with those of UK-treated patients since the start
                      of the national PBT service in 2018.},
      keywords     = {Brain (Other) / late toxicities (Other) / paediatric
                      (Other) / proton beam therapy (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36804292},
      doi          = {10.1016/j.clon.2023.01.024},
      url          = {https://inrepo02.dkfz.de/record/271244},
}