TY  - JOUR
AU  - Rosswog, Carolina
AU  - Fassunke, Jana
AU  - Ernst, Angela
AU  - Schömig-Markiefka, Birgid
AU  - Merkelbach-Bruse, Sabine
AU  - Bartenhagen, Christoph
AU  - Cartolano, Maria
AU  - Ackermann, Sandra
AU  - Theissen, Jessica
AU  - Blattner-Johnson, Mirjam
AU  - Jones, Barbara
AU  - Schramm, Kathrin
AU  - Altmüller, Janine
AU  - Nürnberg, Peter
AU  - Ortmann, Monika
AU  - Berthold, Frank
AU  - Peifer, Martin
AU  - Büttner, Reinhard
AU  - Westermann, Frank
AU  - Schulte, Johannes H
AU  - Simon, Thorsten
AU  - Hero, Barbara
AU  - Fischer, Matthias
TI  - Genomic ALK alterations in primary and relapsed neuroblastoma.
JO  - British journal of cancer
VL  - 128
IS  - 8
SN  - 0007-0920
CY  - Edinburgh
PB  - Nature Publ. Group
M1  - DKFZ-2023-00378
SP  - 1559-1571
PY  - 2023
N1  - 2023 Apr;128(8):1559-1571
AB  - Genomic alterations of the anaplastic lymphoma kinase gene (ALK) occur recurrently in neuroblastoma, a pediatric malignancy of the sympathetic nervous system. However, information on their development over time has remained sparse.ALK alterations were assessed in neuroblastomas at diagnosis and/or relapse from a total of 943 patients, covering all stages of disease. Longitudinal information on diagnostic and relapsed samples from individual patients was available in 101 and 102 cases for mutation and amplification status, respectively.At diagnosis, ALK point mutations occurred in 10.5
LB  - PUB:(DE-HGF)16
C6  - pmid:36807339
DO  - DOI:10.1038/s41416-023-02208-y
UR  - https://inrepo02.dkfz.de/record/271246
ER  -