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000271253 1001_ $$0P:(DE-He78)83275dace99f5b3d2c745bae4297121c$$aNikitina, Ekaterina$$b0$$eFirst author$$udkfz
000271253 245__ $$aBovine meat and milk factor protein expression in tumor-free mucosa of colorectal cancer patients coincides with macrophages and might interfere with patient survival.
000271253 260__ $$aHoboken, NJ$$bJohn Wiley & Sons, Inc.$$c2024
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000271253 500__ $$a#EA:F200#LA:F200# / 2024 May;18(5):1076-1092
000271253 520__ $$aBovine milk and meat factors (BMMFs) are plasmid-like DNA molecules isolated from bovine milk and serum, as well as the peritumor of colorectal cancer (CRC) patients. BMMFs have been proposed as zoonotic infectious agents and drivers of indirect carcinogenesis of CRC, inducing chronic tissue inflammation, radical formation and increased levels of DNA damage. Data on expression of BMMFs in large clinical cohorts to test an association with co-markers and clinical parameters were not previously available and were therefore assessed in this study. Tissue sections with paired tumor-adjacent mucosa and tumor tissues of CRC patients [individual cohorts and tissue microarrays (TMAs) (n = 246)], low-/high-grade dysplasia (LGD/HGD) and mucosa of healthy donors were used for immunohistochemical quantification of the expression of BMMF replication protein (Rep) and CD68/CD163 (macrophages) by co-immunofluorescence microscopy and immunohistochemical scoring (TMA). Rep was expressed in the tumor-adjacent mucosa of 99% of CRC patients (TMA), was histologically associated with CD68+ /CD163+ macrophages and was increased in CRC patients when compared to healthy controls. Tumor tissues showed only low stromal Rep expression. Rep was expressed in LGD and less in HGD but was strongly expressed in LGD/HGD-adjacent tissues. Albeit not reaching statistical significance, incidence curves for CRC-specific death were increased for higher Rep expression (TMA), with high tumor-adjacent Rep expression being linked to the highest incidence of death. BMMF Rep expression might represent a marker and early risk factor for CRC. The correlation between Rep and CD68 expression supports a previous hypothesis that BMMF-specific inflammatory regulations, including macrophages, are involved in the pathogenesis of CRC.
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000271253 650_7 $$2Other$$abovine meat and milk factors
000271253 650_7 $$2Other$$achronic inflammation
000271253 650_7 $$2Other$$acolorectal cancer
000271253 650_7 $$2Other$$ainfectious indirect carcinogenesis
000271253 7001_ $$0P:(DE-He78)88bdc81d9d68a695716ce5b2c82b1bfc$$aBurk-Körner, Amelie$$b1$$eFirst author$$udkfz
000271253 7001_ $$0P:(DE-He78)1042737c83ba70ec508bdd99f0096864$$aWiesenfarth, Manuel$$b2$$udkfz
000271253 7001_ $$0P:(DE-He78)9b2a61b2abe4a64ca23b6783b7c4fe63$$aAlwers, Elizabeth$$b3$$udkfz
000271253 7001_ $$0P:(DE-He78)92c93319837b4b915db8393795faf0b6$$aHeide, Danijela$$b4$$udkfz
000271253 7001_ $$0P:(DE-He78)44a33c775d0e27db79f8fd9e97a99e0a$$aTessmer, Claudia$$b5$$udkfz
000271253 7001_ $$0P:(DE-He78)e228057961cd499cd6acd0ce04076f77$$aErnst, Claudia$$b6$$udkfz
000271253 7001_ $$0P:(DE-He78)2214defe87d04a849413e5eed47c415e$$aKrunic, Damir$$b7$$udkfz
000271253 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b8$$udkfz
000271253 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b9$$udkfz
000271253 7001_ $$avon Winterfeld, Moritz$$b10
000271253 7001_ $$aHerpel, Esther$$b11
000271253 7001_ $$aBrobeil, Alexander$$b12
000271253 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b13$$udkfz
000271253 7001_ $$0P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5$$aHeikenwälder, Mathias$$b14$$udkfz
000271253 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b15$$udkfz
000271253 7001_ $$0P:(DE-He78)bb6a7a70f976eb8df1769944bf913596$$aKopp-Schneider, Annette$$b16$$udkfz
000271253 7001_ $$0P:(DE-He78)42946c81b039c802769d91e486a4d5fb$$aBund, Timo$$b17$$eLast author$$udkfz
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