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@ARTICLE{Valentini:271256,
      author       = {C. Valentini and N. Ebert$^*$ and L. Koi and M. Pfeifer and
                      S. Löck$^*$ and C. Erdmann and M. Krause$^*$ and M.
                      Baumann$^*$},
      title        = {{P}reclinical trial comparing radiotherapy alone versus
                      standard radiochemotherapy in three human papilloma virus
                      ({HPV}) negative and three {HPV}-positive head and neck
                      squamous cell carcinoma ({HNSCC}) xenograft tumour models.},
      journal      = {Radiotherapy and oncology},
      volume       = {183},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-00388},
      pages        = {109546},
      year         = {2023},
      note         = {#LA:E220# / 2023 Jun;183:109546},
      abstract     = {To perform a preclinical trial comparing the efficacy of
                      fractionated radiotherapy versus radiochemotherapy with
                      cisplatin in HPV-positive and negative human head and neck
                      squamous cell carcinoma (HNSCC) xenografts.Three
                      HPV-negative and three HPV-positive HNSCC xenografts in nude
                      mice were randomized to radiotherapy (RT) alone or to
                      radiochemotherapy (RCT) with weekly cisplatin. To evaluate
                      tumour growth time, 20 Gy radiotherapy (± cisplatin) were
                      administered in 10 fractions over 2 weeks. Dose-response
                      curves for local tumour control were generated for RT with
                      30 fractions over 6 weeks to different dose levels given
                      alone or combined with cisplatin (RCT).One of three
                      investigated HPV-negative and two out of three HPV-positive
                      tumour models showed a significant increase in local tumour
                      control after RCT compared to RT alone. Pooled analysis of
                      the HPV-positive tumour models showed a statistically
                      significant and substantial benefit of RCT versus RT alone,
                      with an enhancement ratio of 1.34. Although heterogeneity in
                      response to both RT and RCT was also observed between the
                      different HPV-positive HNSCC, these overall were more RT and
                      RCT sensitive than HPV-negative models.The impact of adding
                      chemotherapy to fractionated radiotherapy on local control
                      was heterogenous, both in HPV-negative and in HPV-positive
                      tumours, calling for predictive biomarkers. RCT
                      substantially increased local tumour control in the pooled
                      group of all HPV-positive tumours whereas this was not found
                      in HPV-negative tumours. Omission of chemotherapy in
                      HPV-positive HNSCC as part of a treatment de-escalation
                      strategy is not supported by this preclinical trial.},
      keywords     = {HNSCC (Other) / HPV (Other) / Radiochemotherapy (Other) /
                      Radiotherapy (Other) / Tumour models (Other)},
      cin          = {E220 / DD01},
      ddc          = {610},
      cid          = {I:(DE-He78)E220-20160331 / I:(DE-He78)DD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36813172},
      doi          = {10.1016/j.radonc.2023.109546},
      url          = {https://inrepo02.dkfz.de/record/271256},
}