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000272829 1001_ $$0P:(DE-HGF)0$$aWang, Shubei$$b0$$eFirst author
000272829 245__ $$aTransgenic HPV11-E2 protein modulates URR activity in vivo.
000272829 260__ $$aLondon$$bChapman & Hall$$c2023
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000272829 500__ $$a#EA:W430#LA:W430# / 2023 Apr;32(1-2):67-76 / Cryopreservation W430
000272829 520__ $$aIn vitro experiments have shown that the E2 protein of human papillomaviruses (HPV) binds to the upstream regulatory region (URR) of the viral genome and modulates transcription. Additionally, it seems to be a necessary component for viral DNA replication together with E1. We have developed a transgenic mouse model containing the URR region of the low-risk virus HPV11 that regulates the expression of the lacZ reporter gene. Most interestingly, in these mice, the transgene was exclusively expressed in the bulge region of the hair follicle but not in any other tissues. Further experimental data indicate that in double transgenic mice that also express the HPV11-E2 protein under the control of the Ubiquitin C-promoter, the transcription of the reporter gene is modulated. When E2 is present, the expression of the reporter gene also occurs exclusively in the bulge region of the hair follicles as it does in the single transgenic mice, but the expression of the lacZ driven by the URR is increased and the statistical spread is greater. Even if the expression of the reporter gene occurs in the hair follicles of the dorsal skin of an animal uniform, E2 obviously has the capacity for both to induce and to repress the URR activity in vivo.
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000272829 650_7 $$2Other$$aHPV-E2
000272829 650_7 $$2Other$$aHuman papillomavirus type 11
000272829 650_7 $$2Other$$aReporter gene
000272829 650_7 $$2Other$$aTransgenic mouse model
000272829 650_7 $$2Other$$aUpstream regulatory region URR
000272829 7001_ $$0P:(DE-He78)3a2ebf39768b8fe8dd25965b08873104$$aGramm, Vera$$b1$$eFirst author
000272829 7001_ $$0P:(DE-He78)26b012bbbc85e8736a8979469a69d9f6$$aLaport, Elke$$b2$$udkfz
000272829 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b3$$udkfz
000272829 7001_ $$0P:(DE-He78)0e9c7f8ab141d513965e8f2237a716b7$$aAlonso, Angel$$b4
000272829 7001_ $$0P:(DE-He78)1b0532fc51fd835d3bb64196e6e751fc$$aSchenkel, Johannes$$b5$$eLast author$$udkfz
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