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@ARTICLE{Wang:272829,
      author       = {S. Wang$^*$ and V. Gramm$^*$ and E. Laport$^*$ and T.
                      Holland-Letz$^*$ and A. Alonso$^*$ and J. Schenkel$^*$},
      title        = {{T}ransgenic {HPV}11-{E}2 protein modulates {URR} activity
                      in vivo.},
      journal      = {Transgenic research},
      volume       = {32},
      number       = {1-2},
      issn         = {0962-8819},
      address      = {London},
      publisher    = {Chapman $\&$ Hall},
      reportid     = {DKFZ-2023-00402},
      pages        = {67-76},
      year         = {2023},
      note         = {#EA:W430#LA:W430# / 2023 Apr;32(1-2):67-76 /
                      Cryopreservation W430},
      abstract     = {In vitro experiments have shown that the E2 protein of
                      human papillomaviruses (HPV) binds to the upstream
                      regulatory region (URR) of the viral genome and modulates
                      transcription. Additionally, it seems to be a necessary
                      component for viral DNA replication together with E1. We
                      have developed a transgenic mouse model containing the URR
                      region of the low-risk virus HPV11 that regulates the
                      expression of the lacZ reporter gene. Most interestingly, in
                      these mice, the transgene was exclusively expressed in the
                      bulge region of the hair follicle but not in any other
                      tissues. Further experimental data indicate that in double
                      transgenic mice that also express the HPV11-E2 protein under
                      the control of the Ubiquitin C-promoter, the transcription
                      of the reporter gene is modulated. When E2 is present, the
                      expression of the reporter gene also occurs exclusively in
                      the bulge region of the hair follicles as it does in the
                      single transgenic mice, but the expression of the lacZ
                      driven by the URR is increased and the statistical spread is
                      greater. Even if the expression of the reporter gene occurs
                      in the hair follicles of the dorsal skin of an animal
                      uniform, E2 obviously has the capacity for both to induce
                      and to repress the URR activity in vivo.},
      keywords     = {HPV-E2 (Other) / Human papillomavirus type 11 (Other) /
                      Reporter gene (Other) / Transgenic mouse model (Other) /
                      Upstream regulatory region URR (Other)},
      cin          = {W430 / C060 / F050},
      ddc          = {590},
      cid          = {I:(DE-He78)W430-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)F050-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36826606},
      doi          = {10.1007/s11248-023-00336-y},
      url          = {https://inrepo02.dkfz.de/record/272829},
}