TY  - JOUR
AU  - Koll, Florestan J
AU  - Metzger, Eric
AU  - Hamann, Jana
AU  - Ramos-Triguero, Anna
AU  - Bankov, Katrin
AU  - Köllermann, Jens
AU  - Döring, Claudia
AU  - Chun, Felix K H
AU  - Schüle, Roland
AU  - Wild, Peter J
AU  - Reis, Henning
TI  - Overexpression of KMT9α Is Associated with Aggressive Basal-like Muscle-Invasive Bladder Cancer.
JO  - Cells
VL  - 12
IS  - 4
SN  - 2073-4409
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-00408
SP  - 589
PY  - 2023
AB  - Muscle-invasive bladder cancer (MIBC) is associated with limited response rates to systemic therapy leading to a significant risk of recurrence and death. A recently discovered histone methyltransferase KMT9, acts as an epigenetic regulator of carcinogenesis in different tumor entities. In this study, we investigated the presence and association of histological and molecular subtypes and their impact on the survival of KMT9α in MIBC. We performed an immunohistochemical (IHC) analysis of KMT9α in 135 MIBC patients undergoing radical cystectomy. KMT9α was significantly overexpressed in the nucleus in MIBC compared to normal urothelium and low-grade urothelial cancer. Using the HTG transcriptome panel, we assessed mRNA expression profiles to determine molecular subtypes and identify differentially expressed genes. Patients with higher nuclear and nucleolar KMT9α expression showed basal/squamous urothelial cancer characteristics confirmed by IHC and differentially upregulated KRT14 expression. We identified a subset of patients with nucleolar expression of KMT9α, which was associated with an increased risk of death in uni- and multivariate analyses (HR 2.28, 95
KW  - MIBC (Other)
KW  - chemotherapy (Other)
KW  - histone methyltransferase (Other)
KW  - molecular subtypes (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36831256
C2  - pmc:PMC9954512
DO  - DOI:10.3390/cells12040589
UR  - https://inrepo02.dkfz.de/record/272835
ER  -