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@ARTICLE{Esen:272836,
      author       = {B. Esen and K. Herrmann$^*$ and S. Bavbek and Y. Kordan and
                      D. Tilki and T. Esen},
      title        = {{P}rostate-specific {M}embrane {A}ntigen {P}ositron
                      {E}mission {T}omography as a {B}iomarker to {A}ssess
                      {T}reatment {R}esponse in {P}atients with {A}dvanced
                      {P}rostate {C}ancer.},
      journal      = {European urology focus},
      volume       = {9},
      number       = {4},
      issn         = {2405-4569},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-00409},
      pages        = {596-605},
      year         = {2023},
      note         = {2023 Jul;9(4):596-605},
      abstract     = {Prostate-specific membrane antigen (PSMA)-targeted positron
                      emission tomography (PET) has superior accuracy for
                      detection of metastatic lesions in patients with prostate
                      cancer (PC). Although PSMA PET has a prominent role in
                      primary and secondary imaging of PC, data on its role in
                      assessing treatment response in advanced PC are limited.To
                      review current data in the literature regarding the impact
                      of antiandrogen therapy on PSMA expression of metastatic
                      sites and the role of serial (baseline and at least 1
                      follow-up scan) PSMA PET to assess treatment response in
                      patients with metastatic PC.A comprehensive literature
                      search in the PubMed database was performed using the terms
                      'PSMA expression prostate', 'PSMA regulation', 'PSMA PET
                      response assessment', and 'serial PSMA PET'.Serial PSMA PET
                      studies (baseline and at least 1 follow-up scan) provide
                      valuable data regarding PSMA expression changes after
                      systemic treatment in patients with metastatic PC. PSMA
                      PET-detected flare and upregulation of PSMA expression
                      following hormonal intervention seem to be early events
                      resolving after 3 mo of treatment. PSMA PET imaging is
                      essential in selecting patients for 177Lu-PSMA radioligand
                      therapy (RLT). Growing evidence favors its use in assessing
                      treatment responses after RLT. Preliminary evidence
                      indicates the value of PSMA PET for assessment of the
                      treatment response in patients receiving systemic treatment
                      other than RLT for metastatic PC.PSMA flare following
                      antiandrogen therapy seems to be an early event and thus PET
                      scans should be performed no earlier than 3 mo after the
                      start of treatment. PSMA PET has a promising role in
                      tailoring treatment according to the specific needs of
                      individual patients and assessing responses following
                      systemic treatment in patients with advanced PC.This review
                      describes how a sensitive imaging method can be used to
                      assess the tumor response to treatment for metastatic
                      prostate cancer.},
      subtyp        = {Review Article},
      keywords     = {Positron emission tomography (Other) / Prostate cancer
                      (Other) / Prostate-specific membrane antigen (Other) /
                      Response to therapy (Other) / Serial imaging (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36842919},
      doi          = {10.1016/j.euf.2023.02.001},
      url          = {https://inrepo02.dkfz.de/record/272836},
}