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000274081 041__ $$aEnglish
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000274081 1001_ $$00000-0002-6927-3360$$aRothwell, Joseph A$$b0
000274081 245__ $$aCirculating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts.
000274081 260__ $$aHeidelberg [u.a.]$$bSpringer$$c2023
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000274081 520__ $$aAmino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69-0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87-0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75-0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89-1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded.Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
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000274081 650_7 $$2Other$$aAmino acids
000274081 650_7 $$2Other$$aColorectal cancer
000274081 650_7 $$2Other$$aGlutamine
000274081 650_7 $$2Other$$aHistidine
000274081 650_7 $$2NLM Chemicals$$aAmino Acids
000274081 650_7 $$00RH81L854J$$2NLM Chemicals$$aGlutamine
000274081 650_7 $$04QD397987E$$2NLM Chemicals$$aHistidine
000274081 650_2 $$2MeSH$$aHumans
000274081 650_2 $$2MeSH$$aAmino Acids
000274081 650_2 $$2MeSH$$aGlutamine
000274081 650_2 $$2MeSH$$aHistidine
000274081 650_2 $$2MeSH$$aBiological Specimen Banks
000274081 650_2 $$2MeSH$$aProspective Studies
000274081 650_2 $$2MeSH$$aColorectal Neoplasms: epidemiology
000274081 650_2 $$2MeSH$$aUnited Kingdom: epidemiology
000274081 7001_ $$aBešević, Jelena$$b1
000274081 7001_ $$aDimou, Niki$$b2
000274081 7001_ $$aBreeur, Marie$$b3
000274081 7001_ $$aMurphy, Neil$$b4
000274081 7001_ $$aJenab, Mazda$$b5
000274081 7001_ $$aWedekind, Roland$$b6
000274081 7001_ $$aViallon, Vivian$$b7
000274081 7001_ $$aFerrari, Pietro$$b8
000274081 7001_ $$aAchaintre, David$$b9
000274081 7001_ $$aGicquiau, Audrey$$b10
000274081 7001_ $$aRinaldi, Sabina$$b11
000274081 7001_ $$aScalbert, Augustin$$b12
000274081 7001_ $$aHuybrechts, Inge$$b13
000274081 7001_ $$aPrehn, Cornelia$$b14
000274081 7001_ $$aAdamski, Jerzy$$b15
000274081 7001_ $$aCross, Amanda J$$b16
000274081 7001_ $$aKeun, Hector$$b17
000274081 7001_ $$aChadeau-Hyam, Marc$$b18
000274081 7001_ $$aBoutron-Ruault, Marie-Christine$$b19
000274081 7001_ $$aOvervad, Kim$$b20
000274081 7001_ $$aDahm, Christina C$$b21
000274081 7001_ $$aNøst, Therese Haugdahl$$b22
000274081 7001_ $$aSandanger, Torkjel M$$b23
000274081 7001_ $$aSkeie, Guri$$b24
000274081 7001_ $$aZamora-Ros, Raul$$b25
000274081 7001_ $$aTsilidis, Kostas K$$b26
000274081 7001_ $$aEichelmann, Fabian$$b27
000274081 7001_ $$aSchulze, Matthias B$$b28
000274081 7001_ $$avan Guelpen, Bethany$$b29
000274081 7001_ $$aVidman, Linda$$b30
000274081 7001_ $$aSánchez, Maria-José$$b31
000274081 7001_ $$aAmiano, Pilar$$b32
000274081 7001_ $$aArdanaz, Eva$$b33
000274081 7001_ $$aSmith-Byrne, Karl$$b34
000274081 7001_ $$aTravis, Ruth$$b35
000274081 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b36$$udkfz
000274081 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b37$$udkfz
000274081 7001_ $$aDerksen, Jeroen W G$$b38
000274081 7001_ $$aColorado-Yohar, Sandra$$b39
000274081 7001_ $$aTumino, Rosario$$b40
000274081 7001_ $$aBueno-de-Mesquita, Bas$$b41
000274081 7001_ $$aVineis, Paolo$$b42
000274081 7001_ $$aPalli, Domenico$$b43
000274081 7001_ $$aPasanisi, Fabrizio$$b44
000274081 7001_ $$aEriksen, Anne Kirstine$$b45
000274081 7001_ $$aTjønneland, Anne$$b46
000274081 7001_ $$aSeveri, Gianluca$$b47
000274081 7001_ $$aGunter, Marc J$$b48
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